血清和脑脊液中脂肪阿拉伯酸甘露聚糖抗体检测对结核性脑膜炎诊断的价值  

VALUE OF DETECTING LIPOPARABINOMANNAN-IgG IN SERUM AND CEREBROSPINAL FLUID FOR DIAGNOSIS OF TUBERCULOUS

作　　者：郑智远[1] 陈琼[1] 海镇环[1] 贺铁生[1] 

机构地区：[1]中南大学湘雅医院呼吸内科,长沙410008

出　　处：《中国现代医学杂志》2001年第3期26-27,共2页China Journal of Modern Medicine

摘　　要：目的 :评估脂肪阿拉伯酸甘露聚糖抗体 (LAM -IgG)检测对结核性脑膜炎的诊断价值。方法 :酶联免疫吸附试验定性检测血清和脑脊液中LAM -IgG。结果 :77例结核性脑膜炎病例中 ,血清LAM -IgG阳性率为45 .45 % ,30例对照组阳性率为 3.33% ,特异性为 96 .6 7% ;脑脊液LAM -IgG阳性率为 48.0 5 % ,特异性为10 0 % ,两者间差异无显著性 (χ2 =0 .0 714,0 .90 >P >0 .75 )。同时检测血清和脑脊液LAM -IgG ,阳性率为5 5 .84% ,特异性为 96 .6 7% ,与单独检测脑脊液LAM -IgG结果比较 ,两者差异有显著性 (χ2 =4.16 6 7,P <0 .0 5 )。结论 :检测血清或脑脊液中LAM -IgG对结核性脑膜炎的诊断有重要临床价值 ,同时检测血清和脑脊液中LAMObjective:To ascertain the value of lipoarabinomannan-IgG(LAM-IgG) determination in the diagnosis of tuberculous meningitis.Methods:LAM-IgG in serum and cerebrospinal fluid was detected with enzyme-linked immunosorbent assay.Results:In 77 patients with tuberculous meningitis,The positive rate of LAM-IgG in serum was 45.45%,the positive rate in 30 control cases was 3.33%,the specificity was 96.67%;the positive rate of LAM-IgG in cerebrospinal fluid was 48.05%,the specificity was 100%,their differences were not remarkable (χ2=0.0714,0.90>P>0.75).Detecting LAM-IgG in serum and cerebrospinal fluid at same time,the positive rate was 55.84%,the specificity was 96.67%,comparing with the positive rate of LAM-IgG in cerebrospinal fluid,their difference was remarkable (χ2=4.1667,P<0.05).Conclusions:Detection of LAM-IgG in serum or cerbrospinal fluid have importance clinic value for diagnosing tuberculous meningitis,and detecting LAM-IgG in serum and cerebrospinal fluid at same time can increase diagnostic rate of tuberculous meningitis.

关 键 词：结核性脑膜炎 血清 脑脊液 脂肪阿拉伯酸甘露聚糖抗体 诊断 

分 类 号：R529.304[医药卫生—内科学]