养阴益气活血冲剂对大鼠脑缺血再灌注氧自由基损伤的保护作用  

Protective Effect of Nourishing Yin,Supplementing Qi and Activating Blood Circulation Powder on Cerebral Ischemia and Reperfusion Oxygen Free Radical Injury of Rats

作　　者：白海波[1] 万海同[1] 严伟民[1] 蔡宇[1] 郑筱祥[1] 

机构地区：[1]浙江大学生物医学工程系,杭州310027

出　　处：《中国中医急症》2001年第2期96-97,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金资助课题!(No.39800192)

摘　　要：目的 观察养阴益气活血冲剂对大鼠脑缺血再灌注氧自由基损伤的保护作用。方法 采用四血管阻断法造成大鼠全脑缺血模型，利用试剂盒测定模型组和用药组血浆和脑匀浆液超氧化物岐化酶 (SOD)活性和丙二醛 (MDA)含量。结果 养阴益气活血冲剂在显著提高缺血再灌注大鼠血浆和脑组织中 SOD活性的同时降低 MDA含量。结论 养阴益气活血冲剂能抑制脂质过氧化反应，提高机体抗氧化能力，对缺血再灌注损伤有较好的治疗作用。To observe the protective effect of nourishing yin, supplementing qi and activating blood circulation powder (NYSQ? ABCP) on cerebral ischemia and reperfusion oxygen free radical injury of rats.Methods:The rat models of whole cerebral ischemia were established by occlusion of four vessels,and superoxide dismutase (SOD),malondialdehyde (MDA) in plasma and brain homogenate in model group and drug? treated group were measured.Results:NYSQABCP significantly increased SOD activity and decreased MDA contents.Conclusion:NYSQABCP can inhibit lipid peroxidation, increase body antioxidation and has protective effect on ischemia and reperfusion injury.

关 键 词：缺血再灌注氧自由基损伤 氧自由基 养阴益气活血冲剂 中医药疗法 

分 类 号：R277.733[医药卫生—中医学]