人工肝支持系统治疗慢性重型病毒性肝炎的临床评价  

Clinical evaluation of treatment with artificial liver support system in chronic fulminant viral hepatitis

作　　者：黄建荣[1] 李兰娟[1] 陈月美[1] 陈江华[1] 朱琮[1] 干梦九[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《中国危重病急救医学》2001年第4期205-208,共4页Chinese Critical Care Medicine

基　　金：国家科技进步二等奖 !(No.15 2 0 0 40 2 );浙江省科技进步一等奖! (No.970 0 0 1)

摘　　要：目的 :探讨人工肝支持系统 (AL SS)治疗慢性重型病毒性肝炎的临床价值。方法 :应用 AL SS治疗 5 5例 (16 2次 )慢性重型肝炎患者 ,并同时选择常规治疗 5 6例患者作为对照组 ;每次 AL SS治疗前后检测生化和免疫指标。结果 :每次 AL SS治疗后患者肝功能显著改善 ,球蛋白降至正常参考值范围 ;血内毒素含量下降 ;但肿瘤坏死因子、白介素 2、白介素 2受体、电解质等每次治疗前后无明显改变 ;AL SS治疗的并发症主要为皮疹、低血压等 ,但大多数患者能耐受 ;临床治愈好转率 6 1.8% ,明显高于对照组 17.9% (P<0 .0 1)。结论 :AL SS是辅助治疗重型病毒性肝炎的有效方法。Objective:To evaluate clinically the treatment with artificial liver support system (ALSS) in chronic fulminant viral hepatitis.Methods:Fiftyfive cases (162 episodes) were treated with ALSS,56 cases with convontional treatment as controls.Immunological and biochemical tests were performed before and after treatment with ALSS.Results:It showed that liver function parameters were markedly improved after treatment with ALSS,e.g.,serum globulin returned to normal,serum endotoxin decreased.There were no changes in levels of tumor necrosis factor(TNF),interleukin2(IL2) as well as interleukin2 receptor(IL2R),and blood electrolyte etc.after ALSS treatment.Complications of ALSS included rash,hypotention etc.,but most patients could tolerated well.Clinical curative rate in ALSS group was much higher than in the controls (61 8% vs.17 9%, P <0 01).Conclusions:Our results showed that ALSS treatment in chronic fulminant viral hepatitis could alleviate the organ damage and improve the clinical curetive rate.

关 键 词：重型病毒性肝炎 慢性 人工肝支持系统 临床评价 治疗 

分 类 号：R512.6[医药卫生—内科学]