新型心肌灌注显像剂^(99m)Tc-tetrofosmin诊断冠心病的价值  

The preliminary clinical study of ^(99m)Tc- tetrofosmin for detecting CAD

作　　者：唐志宏[1] 黄兰君[1] 彭武和[1] 王国英[1] 曾建华[1] 刘伊丽[1] 

机构地区：[1]第一军医大学南方医院,广东广州510515

出　　处：《中国临床医学影像杂志》2001年第1期20-21,共2页Journal of China Clinic Medical Imaging

基　　金：广东省医药卫生科研基金资助(A1998354)

摘　　要：目的：探讨新型心肌灌注显像剂 99mTc－ tetrofosmin诊断冠心病的临床价值。材料与方法：对 59例确诊或疑诊并已行冠状动脉造影的患者进行运动、静息心肌灌注断层显像，分别在运动高峰及静息状态静脉注射 99mTc－ tetrofosmin 740MBq后 30～ 60min按常规方法做 SPECT断层采集。结果：在注射 99mTc－ tetrofosmin后无任何不适反应，并获得良好心肌断层图像；以冠状动脉造影结果为金标准， 99mTc－ tetrofosmin诊断冠心病的灵敏度、特异性及准确度分别为 89. 1％， 84. 6％及 88. 1％。结论： 99mTc－ tetrofosmin具有标记简便、给药后无需脂餐促排、显像时间短、图像质量清晰及诊断准确度较高等特点，有着良好的临床应用前景。Objective:To assess the clinical value of 99mTc- tetrofosmin in the diagnosis of coronary artery disease(CAD).Materials and Methods:Fifty- nine patients who had coronary angiography had myocardial perfusion imaging at 30～ 60 minutes after intravenous injection of 99mTc- tetrofosmin.The findings of stress and rest myocardial tomography were compared with coronary angiography.Results:No side effects had been discovered.Excellent myocardial images with high contrast were obtained.The sensitivity,specificity and accuracy of 99mTc- tetrofosmin in detecting CAD were 89. 1％， 84. 6％ and 88. 1％ ,respectively.Conclusions:99mTc- tetrofosmin perfusion tomography is a feasible and valuable means for identification of patient with CAD.

关 键 词：放射性核素显像 冠状动脉疾病 诊断 

分 类 号：R541.404[医药卫生—心血管疾病]