部分脾动脉栓塞后机体体液免疫的变化  

The changes of humoral immunity after partly splenic artery embolization

作　　者：郭顺林[1] 王文辉[1] 王世杰[1] 张皓[1] 雷军强[1] 陈辉[1] 赵季军[1] 常香惠[1] 

机构地区：[1]兰州医学院第一附属医院放射科,甘肃兰州730000

出　　处：《中国临床医学影像杂志》2001年第1期25-27,共3页Journal of China Clinic Medical Imaging

基　　金：甘肃省教委资助项目

摘　　要：目的：观察部分脾动脉栓塞治疗继发性脾功能亢进后机体体液免疫的变化。材料与方法： 32例肝炎、肝硬化、继发性脾功能亢进者，在 DSA引导下，把 5F RS型或 Yashiro导管选择性地插入脾动脉内， 1mm× 1mm× 1mm明胶海绵块 120～ 180枚与抗菌素和造影剂混合后，在透视监视下分次注入脾动脉。栓前、栓后 1、 3、 7、 14、 28和 56天分别抽血 3ml，测定血清中 IgG、 IgA、 IgE、白介素－ 2和肿瘤坏死因子的含量。结果：栓塞后动脉期，脾动脉 5级以下分支未显影，实质期 70％～ 90％脾实质未显影。栓后不同时期，血清中 IgG、 IgA、 IgE、白介素－ 2和肿瘤坏死因子含量无显著性变化。结论：部分脾动脉栓塞治疗脾功能亢进，保留了部分脾脏组织，对机体体液免疫功能无显著影响。Objective:To observe the changes of organism humoral immunity after embolization treatment for secondary hypersplenism.Materials and Methods:In 32 cases with hepatitis,posthepatitic cirrhosis and secondary hypersplenism,5F RS type or Yashiro catheter was placed selectively into the splenic artery by DSA fluoroscopy,120～ 180 masses of 1mm× 1mm× 1mm gelfoam mixed with antibiotic and contrast medium together were injected fractionaly,3ml of blood was drawn before and every 1,3,7,14,28 and 56 days after embolization to determine the content of IgG,IgM,IgE,interleukin－ 2(IL－ 2)and TNF in blood serum.Results:After partial embolization of splenic artery,splenic arterial distal to the 5th grade of splenic arterial branch, did not develope in arterial phase,70％～ 90％ spleen parenchyma did not enhanced in parenchymal phase,no obvious changes in the content of IgG,IgA,IgE,IL－ 2 and TNF in serum during different phases after embolization.Conclusion:Partial splenic artery embolization didn t have outstanding influence on the function of organism immunoglobulin IgG,IgA,IgE and cytokine IL－ 2 and TNF.

关 键 词：治疗性栓塞 抗体生成 脾功能亢进 

分 类 号：R657.63[医药卫生—外科学] R815[医药卫生—临床医学]