对氨基水杨酸异烟肼对耐INH及PAS结核菌株的耐药实验观察  

Drug resistance observation on pasiniazide for the TB bacteria resistant to INH and PAS

作　　者：孙丽[1] 席家宁[1] 康丽君[1] 晏华琪[1] 

机构地区：[1]北京胸科医院,100095

出　　处：《中国防痨杂志》2001年第2期110-111,共2页Chinese Journal of Antituberculosis

摘　　要：目的　了解对氨基水杨酸异烟肼 (PSNZ)对耐异烟肼 (INH)及对氨基水杨酸钠 (PAS)的结核菌株耐药情况。方法　用改良罗氏培养基观察 36株同时耐INH和PAS及 1 49株对INH和PAS敏感的结核菌株对PSNZ药敏结果。结果　 36株耐INH和PAS的结核菌株在 1 μg/ml浓度下有 44.4%的菌株对PSNZ有效 ,1 49株对INH和PAS均敏感的结核菌株在 1 μg/ml浓度下有 96%的结核菌株对PSNZ敏感。结论　PSNZ对耐INH和 /或PAS的结核菌株仍显示一定程度的敏感 ,是一种独立的抗结核药物 ,可作为治疗耐多药结核病的有效药物之一。Objective To determine the PSNZ drug resistance incidence among INH and PAS-resistant M.tuberculosis.Methods By applying the reformed L-J medium, observe and compare the drug-resistance and drug-susceptibility to PSNZ in 36 INH and PAS resistant-M. tuberculosis, and 149 INH and PAS sensitive M. tuberculosis.Results 44.4% of the 36 INH and PAS resistant-M. tuberculosis are susceptible to PSNZ at the concentration of 1μg/ml; 96% of the 149 INH and PAS sensitive M. tuberculosis are susceptible to PSNZ at the concentration of 1μg/ml.Conclusion PSNZ is still effective to some of the TB bacteria resistant to INH and/or PAS. It is an independent anti-TB drug. It can be used as one of the effective drugs for treat the MDR-TB.

关 键 词：对氨基水杨酸异烟肼 结核分枝杆菌 耐药性 INH PAS PSNZ 

分 类 号：R446.5[医药卫生—诊断学]