抗衰神方对^(60)Co_γ线照射小鼠免疫功能的影响  

Effect of Kang Shuai Shen Fang(抗衰神方)on Immune Functions of(50)~Co γ-Ray Irradiated Mice

作　　者：巩平[1] 谢蜀生[1] 秦凤华[1] 张文仁[1] 龙振洲[1] 陈可冀[2] 李春生[2] 张国玺[2] 

机构地区：[1]北京医科大学免疫教研室,北京100083 [2]中国中医研究院西苑医院

出　　处：《中西医结合杂志》1991年第11期671-673,共3页

摘　　要：本文报道了抗衰神方可明显增强^(60)Co γ线照射损伤小鼠对同种异型抗原诱导的迟发型超敏反应和混合淋巴细胞反应,明显增强放射损伤小鼠脾细胞对刀豆蛋白 A(ConA)的增殖反应,明显增加放射损伤小鼠特异的抗体分泌细胞数及增强脾细胞对细菌酯多糖(LPS)的增殖反应,并能促进 ConA 刺激的小鼠脾细胞分泌白细胞介素-Ⅱ。证明了抗衰神方对放射线损伤小鼠非特异和特异的细胞免疫和体液免疫功能恢复具有明显的促进作用。In this paper we reported that Kang Shuai Shen Fang (KSSF) could recover the immune functions of irradiated mice. The results indicated that KSSF is able to enhance the proliferation response of spleen cells of irradiated mice to Con A and LPS.At the dosage of 400 mg/kg·d,KSSF can stimulate the production of plaque forming cells,the DTH response induced by allogeneic splenocytes.The mixed lymphocyte reaction was much stronger in the drug-receiving irradiated group than that in the control group.Further study indicated that KSSF is able to enhance the production of interleukin 2 in irradiated mice.

关 键 词：抗衰神方 免疫缺损 白细胞介素-Ⅱ 免疫功能恢复 小鼠 中医药治疗 钴^60Coγ线照射 

分 类 号：R285.5[医药卫生—中药学]