石斛小菇的药理活性研究  

STUDIES ON PHARMACOLOGICAL ACTIVITY OF MYCENA DENDROBII

作　　者：王春兰[1] 陈晓梅[1] 郭顺星[1] 刘新民[1] 孙绍美[1] 王圣平[1] 尚伟芬[1] 

机构地区：[1]中国医学科学院中国协和医科大学药用植物研究所,北京100094

出　　处：《微生物学通报》2001年第2期73-76,共4页Microbiology China

基　　金：国家自然科学基金资助项目!(No.39770017)&&

摘　　要：对分离自野生铁皮石斛中的一种新的内生真菌石斛小菇进行了初步的药理活性测定，发现石斛小菇的发酵液对小鼠中枢神经系统有兴奋作用，石斛小菇苗丝体和发酵液的粗提物具有与中药石斛相似的镇痛作用，并结合化学方法确定了石斛小菇粗提物中与其镇痛药效相对应的活性部位。The pharmacological activity of Mycena dendrobii Fan et Guo, a new species of endophytic fungus was studied. It was revealed that the mycelia methanol extracts and the fermentation liquid ethanol extracts of Mycena dendrobii showed anglgesic effect to mice, which have the correlations to that of the traditional Chinese medicine 'shihu'. The fermentation liquid ethanol extracts of Mycena dendrobii showed excitation effect to central nervous system of mice. Then the effective parts of anglgesic effect was determined.

关 键 词：石斛小菇 药理作用 镇痛 

分 类 号：Q939[生物学—微生物学]