甘草总黄酮清除羟自由基作用的体外实验探讨  

The scavenging effect of flavoniods of glycyrrhiza on hydroxyl radical studied in vitro

作　　者：吴碧华[1] 龙存国[1] 王晓明[1] 李秋茹[1] 郑霞清[1] 胡常林[2] 

机构地区：[1]川北医学院附属医院神内科,四川南充637000 [2]重庆医科大学附二院神内科,重庆400042

出　　处：《川北医学院学报》2001年第1期3-5,共3页Journal of North Sichuan Medical College

摘　　要：甘草总黄酮对Fenton反应生成的·OH具有较强的直接清除作用 ,该作用明显优于甘露醇 ,其清除·OH的IC50 是甘露醇的 1/2 5 5 ,其抑制·OH生成的IC50 是甘露醇的 1/139。结果提示了甘草总黄酮有可能作为一种新的天然抗氧化剂。Flavionoids of Glycyrrhiza possessed significantly Scavenging effect on hydroxyl radical(·OH) produced by Fenton reaction.the effect of Flavonoids of Glycyrrhiza was more potent than that of mannitol.the ·OH-scavening IC 50 and the ·OH-inhibting IC 50 of in were 1/25 and 1/139 respectively as compared with that of mannitol.the results suggest Flavoniods of Gycyrrhiza with a vast prospect as a new natural antioxidant.

关 键 词：甘草总黄酮 羟自由基 抗氧化剂 中药 体外实验 

分 类 号：R286.79[医药卫生—中药学] R285.5[医药卫生—中医学]