美托洛尔对家兔在体心脏早期后除极的电生理作用  

The electrophysiological effect of the metoprolol on the early afterdepolarization in rabbit heart in vivo

作　　者：余更生[1] 孙尧[2] 李万镇[3] 李小梅[3] 

机构地区：[1]重庆医科大学儿童医院内科,重庆400014 [2]华北煤炭医学院附属医院心内科 [3]北京大学第一医院儿科

出　　处：《临床心血管病杂志》2001年第4期173-174,共2页Journal of Clinical Cardiology

摘　　要：目的 :研究美托洛尔对家兔在体心脏早期后除极 (EAD)的影响 ,以探讨美托洛尔治疗室性心律失常的机制。方法 :应用接触电极记录心内膜单相动作电位 (MAP)技术 ,观察氯化铯诱发 EAD时使用美托洛尔对心脏的电生理作用。结果 :美托洛尔可以减低 EAD的振幅 [其 EAD%达 (2 6 .2 5± 1.84) % ],与对照组比较 [其EAD%达 (33.8± 4.36 ) % ]差异有显著性意义 (P <0 .0 5 )。结论 :后除极是心律失常发生的机制之一 ,美托洛尔对 EAD有抑制作用 ,为美托洛尔治疗某些心律失常提供了理论依据。Objective:The goal of this study was to discuss how metoprolol caused electrophysiological effect on the early after depolarization (EAD) in rabbit heart and to research on the mechanism of treatment of arrhythmias with metoprolol.Method:A Franz 6F catheter was introduced into the left ventricle to record monophasic action potentials (MAPs) using the contact electrode technique and to observe the change of MAP in CsCl induced EAD when metoprolol was administered. Result:The metoprolol could reduce the amplitude of early after depolarization [EAD% add up to ( 26.25 ± 1.84 )%],which had significant difference (P< 0.05 ) compared with the control group [EAD% up to ( 33.8 ± 4.36 )%].Conclusion:After depolarization is one of the mechanisms of arrhythmia. The use of metoprolol can inhibit the early after depolarization, and this provides a theoretical proof for the use of metoprolol to treat some arrhythmias in clinic.

关 键 词：心律异常 美托洛尔 动作电位 电生理 家兔 EAD 

分 类 号：R541.7[医药卫生—心血管疾病] R972[医药卫生—内科学]