Ⅰ型糖尿病胰岛移植术后代谢特征的观察和分析  

Postoperative metabolic characteristics of islet transplantation in the treatment of type Ⅰ diabetes

作　　者：文武[1] 龚家镇[1] 孟庆敏[1] 周鸣淑[1] 刘惠玲[1] 

机构地区：[1]首都医科大学附属北京同仁医院外科,100730

出　　处：《中华普通外科杂志》2001年第3期136-138,共3页Chinese Journal of General Surgery

摘　　要：目的　探讨Ⅰ型糖尿病患者胚胎胰岛移植术后代谢状况与移植物的功能及存活的关系。方法　将培养后的胎儿胰岛细胞移植至 2 6例Ⅰ型糖尿病患者的大网膜及小网膜腔内 ,比较患者的各项代谢指标与移植效果之间的关系。结果　本组术后胰岛素用量均有明显减少 (P <0 0 5 ) ,血清C肽及胰岛素水平升高。术后 13例患者空腹血清C肽≥ 0 5ng/ml,9例≥ 0 5ng/ml持续超过1年。结论　胰岛移植是治疗Ⅰ型糖尿病的有效方法。Objective To assess the effect of fetal islet transplantation for the treatment of Type Ⅰ diabetes. Methods The pancreatic islets from human aborted embryos were cultured and implanted into the greater omentum and omental bursa of 26 patients with type Ⅰ diabetes. The function of transplanted islets was evaluated. Results After transplantation, the exogenous insulin requirement significantly decreased (P<005). The fast serum C-peptide level was ≥ 05*!ng/ml in 13 transplanted patients, and ≥ 05 ng/ml in 9 cases for more than one year, among them one case has been on normal level for 14 years. Conclusion Islet transplantation is an effective way for the treatment of type Ⅰ diabetes.

关 键 词：胰岛素依赖型糖尿病 胰岛移植 手术后 代谢特征 

分 类 号：R657.5[医药卫生—外科学]