海洛因中毒性脑病——附5例临床分析  

Toxic encephalopathy caused by heroin： clinical analyses of five cases

作　　者：杨宁[1] 高敏[2] 高聪[1] 

机构地区：[1]广州医学院第二附属医院神经内科,广东广州510260 [2]广东省第二中医院

出　　处：《罕少疾病杂志》2001年第1期6-8,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的报道和分析 5例海洛因中毒性脑病患者的临床资料，探讨该病的诊断及可能的发病机制。方法详细询问病史，头颅 MRI和其它辅助性检查以及治疗和转归分析。结果治疗 1个月后， 4例患者感觉运动功能基本恢复，精神症状不同程度减轻； 2例遗留计算力、记忆力差；死亡 1例，死因为出院后再次吸毒过量引起呼吸衰竭。结论根据患者明确的吸毒史以及一系列神经精神症状和神经系统阳性体征、头颅 MRI特征性改变，该病可有明确的诊断。其发病机制除与海洛因直接损害中枢神经系统有关外，还与黑市上出售的低纯度海洛因引起脱髓鞘病变有关。Objective To discuss the main points of diagnosis and the pathogenesis of toxic encephalopathy caused by heroin on the base of reporting and analyzing the clinical materials of five cases. Methods Detailed asking of history,cranium MRI and other adjuvant medical examinations,analysis of therapy and prognosis were made. Results After 1 month treatment,4 cases,function of sensation and movement recovered,mental symptom abated in various degress.Poor counting ability and memorization were left in 2 cases.1 case died from respiratory failure caused by re－ taking addictive drugs after discharging. Conclusion According to unequivocal history of taking addictive drugs,a series of nervous and mental symptom and sign,characteristic change of cranium MRI,the toxic encephalopathy caused by heroin could be diagnosed.The pathogenesis may be related to damage in central nervous system caused by heroin directly.In addition,diseases myelinoclasis caused by low degree of purity of heroin sold in black market were considered.

关 键 词：海洛因中毒性脑病 诊断 发病机制 

分 类 号：R595.506[医药卫生—内科学] R747.9[医药卫生—临床医学]