^(99m)Tc-甲氧基异丁基异腈测定槲皮素磷酸酯钾对小鼠心肌营养性血流的影响  

The effect of potassium quercetin phosphate on the nutritional blood flow of mouse heart

作　　者：汤允昭[1] 陶然[1] 郝一彬[1] 王志平[1] 范光灿 高宙[2] 

机构地区：[1]山西医学院 [2]山西医学院第一附属医院

出　　处：《核技术》1991年第11期670-672,共3页Nuclear Techniques

摘　　要：采用^(99m)Tc-甲氧基异丁基异腈(MIBI)示踪剂测定槲皮素磷酸酯钾(PQP)对小鼠心肌营养性血流的影响。实验表明ip PQP 200mg/kg可使小鼠每克心肌^(99m)Tc-MIBI的摄取能力与对照组相比增加55.36％,这一结果表明PQP有增加心肌营养性血流的作用,同时也表明可以用^(99m)Tc-MIBI替代^(36)Rb测定心肌营养性血流。The effect of potassium quercetin phosphate (PQP) on the nutritional blood flow of mouse heart was evaluated with the radioactive tracer 99mTc-hexakis-2-methoxyisobutyl isonitrile (MIBI). The result showed that the uptake of 99mTc-MIBI by mouse heart (per gram) in the PQP-treated group (ip 200 mg/kg) was increased by 55.36% as compared with control group. This suggests that PQP can increase the nutritional blood flow of mouse heart. 99mTc-MIBI may take the place of 86Rb in evaluating nutritional blood flow of myocardium in animals and men.

关 键 词：锝99 MIBI PQP 心肌 营养性血 

分 类 号：R972[医药卫生—药品]