柔红霉素预防晶状体后囊膜混浊的实验研究  

Experiment study of preventing from posterior capsular opacity by daunomycin

作　　者：陈新宇[1] 刘晓宁[1] 孙艳西[1] 吴登雷[1] 

机构地区：[1]江苏省镇江市第一人民医院眼科,212002

出　　处：《临床眼科杂志》2001年第1期80-81,共2页Journal of Clinical Ophthalmology

摘　　要：目的　通过动物实验探讨柔红霉素预防白内障术后的后囊膜混浊的作用及临床应用价值。方法　采用柔红霉素 5 .0μg/ m l、7.5μg/ m l两种浓度在兔眼晶状体囊外摘除术中行囊袋内灌注 5分钟。通过裂隙灯显微镜观察其术后反应。术后 3个月取眼球做病理切片观察组织的毒性反应。结果　随访 3个月 ,用药组后发障的发生率明显减低 ,未发现角膜、葡萄膜及视网膜的毒性反应。结论　柔红霉素术中一次性囊袋内灌注 ,可减少后囊混浊的发生率 ,并对周围组织无损伤。安全、有效、方便使柔红霉素在后囊混浊预防方面有临床应用价值。Objective To investigate the effect of daunomycin as a preventer of posterior capsule opacification(PCO),and the applicability in clinical procession by animal experiments.Methods To infuse 5.0ug/ml,7.5ug/ml daunomycin into les capsular bag for five minutes during ECCE operation on rabbit eyes(20 cases).The post-operative response of eye tissue was observed under slit lamp microscop.At postoperative 3 months ,the ocular pathological changes was observed by light microscope.Results With three months follow-up,it was found that the incidence of PCO decreased in the drug group,without any cornea or uveitis,retina damage.Conclusions The study indicated that the incidence of PCO could be reduced by single intraocular infusion of daunomycin without toxicity to adjacent ocular tissues.Its efficiency,safety and simplicity sugest that daunomycin can be valuable for the provention of PCO during clinical application.

关 键 词：柔红霉素 后囊膜混浊 白内障囊外摘除术 治疗 

分 类 号：R965[医药卫生—药理学]