氯氮平与利培酮对血清催乳素水平的影响  

The effects of clozapine and risperidone on serum prolactin levels of female schizophrenia

作　　者：侯静[1] 徐贵云[1] 马崔[1] 吴福喜[1] 黎德美[1] 陆欣乔[1] 朱海兵[1] 

机构地区：[1]广州市精神病医院,510370

出　　处：《临床精神医学杂志》2001年第1期1-3,共3页Journal of Clinical Psychiatry

基　　金：广东省医学科学技术研究基金立项!项目号 B199915 4

摘　　要：目的 :了解氯氮平或利培酮对首发女性精神分裂症患者血清催乳素水平的变化。　方法 :采用 EL ISA方法测定血清催乳素水平。　结果 :治疗后氯氮平组血清催乳素水平没有显著变化 ,而利培酮组血清催乳素水平显著升高。　结论 :催乳素水平不能说明精神分裂症发病及严重程度 ,也不能作为非典型抗精神病药疗效的指标。Objective:To assess the serum prolactin levels of female first onset schizophrenia in the treatment of clozapine and risperidone. Method:ELISA had been used to determine the serum prolactin levels. Results:The serum prolactin levels of risperidone treated patients increased significantly 10 weeks later, while those of clozapine treated patients showed no obvious change. Conclusion:Neither can the serum prolactin levels explain the pathogenesis and severity of schizophrenia, nor predict the clinical outcome of atypical antipsychotics.

关 键 词：精神分裂症 氯氮平 利培酮 催乳素 

分 类 号：R971.4[医药卫生—药品]