冠心病患者餐后血脂、LDL氧化活性的变化  

The postprandial lipemia,oxidative susceptibility of LDL in patients with coronary heart disease

作　　者：蔡红琳[1] 章慧[1] 李三潭[2] 

机构地区：[1]同济医科大学附属协和医院营养科,武汉430022 [2]同济医科大学心血管病研究所

出　　处：《中国临床营养杂志》2001年第1期35-38,共4页Chinese Journal of Clinical Nutrition

摘　　要：目的　探讨冠心病患者餐后血脂代谢情况。　方法　对 11例冠心病患者 (冠心病组 )和 15例健康者 (对照组 )予低脂饮食 2周后进食脂肪餐。于餐前、餐后 2、4、6、8h采血 ,检测血TG、TC、LDL C、HDL C、LPO及LDL C的氧化活性LPO LDL C。　结果　冠心病组餐前TG (P <0 .0 0 1)、LDL C(P <0 .0 1)极显著高于对照组 ,HDL C(P <0 .0 0 1)极显著低于对照组 ,LPO (P <0 .0 0 1)、LDL LPO C(P <0 .0 1)均极显著高于对照组。冠心病组餐后各点TG(P <0 .0 1)极显著高于对照组 ,HDL C(P <0 .0 0 1)极显著低于对照组 ,LPO(P <0 .0 0 1)、LDL LPO C(P <0 .0 0 1)极显著高于对照组。多元回归分析表明餐后血脂 (TG AUC)与冠心病发生密切相关。冠心病组餐后 8h的TG值 (P <0 .0 0 5 )显著高于餐前 ,餐后各时段LDL LPO C(P <0 .0 0 1)极显著高于餐前 ,对照组餐后各时段LDL LPO C(P <0 .0 0 1)极显著高于餐前。　结论　冠心病患者存在餐后高血脂 ,餐后高血脂与冠心病发生密切相关 ,冠心病患者餐后LDL C代谢异常 ,对氧化剂敏感性增强 ,脂质过氧化物明显增加。Objective To study the postprandial lipid metabolism in patients with coronary heart disease. Methods 11 CHD cases as CHD group and 15 normal as control group were selected to undergo oral fat load test. Blood samples were obtained before test and 2,4,6 and 8 hours after test. Serum TG, TC, LDL-C,HDL-C, LPO and LDL-LPO-C were calculated. Results 1.Preprandial TG, LDL-C, LPO and LDL-LPO-C in CHD group were significantly higher than that of control group. 2. Postprandial TG, LPO, LDL-LPO-C in CHD group were significantly higher than that of control group. Postprandial HDL-C in CHD group were significantly lower than control group. 3. Postprandial TG (8h), LDL-LPO-C in CHD group were significantly higher than in the preprandial. Postprandial LDL-LPO-C in control group was significantly higher than preprandial. Conclusions 1. Postprandial high-lipemia and dyslipemia was obvious in CHD group. 2. Postprandial high-lipemia was closely related to the development of CHD. 3. Postprandial LDL-LPO-C in CHD group increased significantly and LDL-C sensitivity to oxidative intensified with postprandial time. 4. Postprandial LPO in CHD group increased significantly.

关 键 词：冠心病 口服脂肪负荷试验 餐后血脂 过氧化脂质 

分 类 号：R541.4[医药卫生—心血管疾病]