1-(2,6-二甲基苯氧基)-2-(3,4-二甲氧基苯乙氨基)丙烷盐酸盐对大鼠膀胱内压及前列腺增生的作用  

Effect of 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethyl- amino) propanehydrochloride on cystometry and benign prostatic hyperplasia in rats

作　　者：郑恒[1] 钱家庆[1] 邵春丽[1] 夏霖[2] 倪沛洲[2] 

机构地区：[1]华中科技大学同济医学院药理学教研室,湖北武汉430030 [2]中国药科大学有机化学教研室,江苏南京210009

出　　处：《中国药理学与毒理学杂志》2001年第2期150-154,共5页Chinese Journal of Pharmacology and Toxicology

摘　　要：在离体兔膀胱颈平滑肌 ,1 (2 ,6 二甲基苯氧基 ) 2 (3,4 二甲氧基苯乙氨基 )丙烷盐酸盐 (DDPH)使去氧肾上腺素所致平滑肌收缩的量效曲线平行右移 ,最大反应不变 ,pA2 值为 7.2 4 ;DDPH 2 5,50mg·kg- 1ig能显著降低麻醉大鼠膀胱容积 ,排尿压 ,排尿阈值压 ;DDPH 12 .5,2 5及 50mg·kg- 1·d- 1ig 4周还可抑制丙酸睾酮所致大鼠前列腺组织的增生 .实验结果提示DDPH有抗前列腺增生及改善尿流率的作用 .Dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino) propane hydrochloride(DDPH) caused parallel rightward shifts of the phenylephrine(Phe) concentration-contractile response curves and did not suppress the maximal contractile response to Phe (pA 2=7.24) in isolated rabbit urinary bladder smooth muscle. DDPH decreased the parameters of cystometry in urethane-anesthetized rats. Thirty minutes after DDPH (25 and 50 mg·kg -1 ig) administration, bladder capacity, voiding pressure, voiding threshold pressure were significantly decreased. With the observation of light-microscope and electron-microscope technique, DDPH (25 and 50 mg·kg -1 ·d -1 ig for 4 weeks) also inhibited the development of testosterone propionate-induced benign prostatic hyperplasia in rats. The results indicate that DDPH may inhibit benign prostatic hyperplasia and improve the urinary flow.

关 键 词：丙烷盐酸盐 膀胱内压 前列腺增生 DDPH 

分 类 号：R965[医药卫生—药理学]