体外循环心脏手术中复方丹参注射液对胃肠道保护作用的临床观察  

Clinical Observation on Gastrointestinal Protective Effect of Composite Salviae Injection in Patients Undergoing Cardio-Pulmonary Bypass Heart Surgery

作　　者：郑利民[1] 刘小玲[1] 夏中元[2] 

机构地区：[1]广东省深圳市中心医院麻醉科,广东518036 [2]湖北医科大学附属第一医院麻醉学教研室

出　　处：《中国中西医结合杂志》2001年第3期177-179,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的 :探讨复方丹参注射液 (简称丹参液 )对体外循环 (CPB)心脏手术中胃肠道的保护作用。方法 :18例在体外循环下行心室间隔缺损或心房间隔缺损修补术患者 ,随机均分为两组 :丹参组在CPB前静脉滴注丹参液 0 5ml/kg ,对照组则注入等量生理盐水。两组均采用张力计法测定胃粘膜内 pH。 结果 :与CPB前比较 ,对照组胃粘膜内 pH于CPB中及CPB后 1、2h显著下降 (P <0 0 5或P <0 0 1) ,丹参组除CPB中胃粘膜内pH显著下降 (P <0 0 5)外 ,CPB后 1、2h均无显著性改变 ;两组间相比较 ,丹参组在CPB中及CPB后 1、2h ,胃粘膜内 pH均显著高于对照组 (P <0 0 5)。 结论Objective: To observe the gastrointestinal protective effect of Composite Salviae Injection (CSI) in patients undergoing cardio pulmonary bypass (CPB) heart surgery. Methods: Eighteen patients, who were scheduled to cardiac surgery (either atrial or ventrical septal repairing) undergoing CPB were randomized equally into two groups. Before CPB, the CSI group was treated with CSI 0.5ml/kg by intravenous dripping and the control group was treated with normal saline in equal volume. The intragastric mucosa pH value (pHi) of patients was monitored by tensiometer. Results: As compared with the pre CPB value, pHi lowered significantly during, 1h and 2 hrs after CPB in the control group (P<0 05 or P<0 01), while in the CSI group, pHi lowered significantly only during CPB (P<0 05), but with insignificant change at 1h and 2 hrs after CPB. Comparison between the two groups showed that pHi value in the CSI group was higher significantly than that in the control group at all respective monitoring period (P<0 05). Conclusion: CSI has gastrointestinal protective effect in patients undergoing CPB cardiosurgery to some extent.

关 键 词：复方丹参注射液 体外循环 心脏手术 胃粘膜内pH 胃肠道保护 

分 类 号：R654.2[医药卫生—外科学]