桂枝汤对发热及低体温大鼠下丘脑中腺苷酸环化酶和磷酸二酯酶活性的影响  

Effect of Guizhi Decoction on Adenyl Cyclase and Phosphodiesterase in Hypothalamus of Rats Models of Fever and Hypothermia

作　　者：齐云[1] 霍海如[1] 田甲丽[1] 郭淑英[1] 李晓芹[1] 周爱香 邹德嵩[2] 姜廷良[1] 

机构地区：[1]中国中医研究院中药研究所药理室 [2]北京联合大学

出　　处：《中国中西医结合杂志》2001年第3期203-205,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家"九五"攀登计划预选项目 !(中药现代化关键问题的基础研究 )资助课题 (No .970 2 1 1 0 1 8)

摘　　要：目的 :观察桂枝汤对发热和低体温模型大鼠下丘脑中腺苷酸环化酶 (AC)和磷酸二酯酶(PDE)活性的影响。方法 :采用放射性同位素方法测定模型动物下丘脑中AC及PDE活性。结果 :在酵母诱导发热模型大鼠中 ,桂枝汤可使下丘脑中AC活性明显降低 (P <0 0 5) ;而在安痛定诱导的低体温模型大鼠中 ,它可使AC活性明显增强 (P <0 0 5)。在两种模型中 ,桂枝汤对PDE活性的影响均不明显。结论 :桂枝汤对体温的双向调节作用可能是部分通过影响AC活性来实现的。Objective: To observe the effect of Guizhi Decoction (GZD) on adenyl cyclase (AC) and phosphodiesterase (PDE) activities in hypothalamus of rat models of fever and hypothermia. Methods: The AC and PDE activities in hypothalamus were determined using radio isotope method. Results: GZD could lower the AC activity in yeast induced fever rat model (P<0 05), but cause rise of AC activity in aminopyrine induced hypothermia model (P<0 05). No significant influence of GZD on PDE activity was shown in both fever or hypothermia models. Conclusion: The bi directional thermo regulation effect of GZD might be partially due to influence on AC activity.

关 键 词：桂枝汤 体温双向调节 腺苷酸环化酶 磷酸二酯酶 

分 类 号：R285.5[医药卫生—中药学]