我国哈萨克族与汉族维生素D受体基因多态性的分布  

Distribution of vitamin D receptor gene polymorphism in Kazakh and Han

作　　者：陈瑞英[1] 冷兴文[1] 阿丽亚[1] 李红[1] 蒋银花[1] 陶国枢[2] 张红红[2] 刘建伟[2] 高宇红[2] 

机构地区：[1]兰州军区乌鲁木齐总医院老年病科,新疆乌鲁木齐830000 [2]解放军总医院老年医学研究所

出　　处：《第四军医大学学报》2001年第8期757-758,共2页Journal of the Fourth Military Medical University

摘　　要：目的　为研究我国哈萨克族与汉族维生素 D受体基因多态性分布与骨质疏松的关系 .方法　采用聚合酶链反应(PCR)限制性片段长度多态性技术 ,对哈萨克族 (年龄 5 0± 2岁 )的健康妇女 93例 ,和汉族 (年龄 5 9± 3岁 )健康妇女 179例进行 VDR基因检测 .结果　在中国哈萨克族 93例中 ,bb型 44例 (4 7% ) ,Bb型 45例 (4 8% ) ,BB型 4例 (4 % ) ;在汉族179例中 ,bb型 16 2例 (90 % ) ,Bb型 17例 (10 % ) ,未见 BB型 .结论　中国哈萨克族 VDR基因多态性分布与汉族相比存在非常显著性差异 (P<0 .0 0 5 ) .AIM To explore the difference between Kazakh and the Han in the distribution of vitamin D receptor(VDR) gene polymorphism. METHODS VDR genotypes in 179 health postmenopausal women of the Han nationality (age:59±3 years),and in 93 those of the Kazakh (age: 50±2 years),and also in 17cases of osteoporosis patients were ana lyzes by polymerase chain reaction restriction fragment length polymorphism. RESULTS Frequencies of bb,Bb and BB genotype are 90%,10% and 0% in the the Han,and 47%,48% and 4% in the Kazakh respectively. A significant difference is found in the frequency distribution of VDR genotype between the Han and the Kazakh ( P <0.005). CONCLUSION Han and Kazakh differ in the frequency distribution of VDR genotype.

关 键 词：受体 维生素D 基因多态性 骨质疏松 哈萨克族 

分 类 号：R681[医药卫生—骨科学]