法莫替丁口溶片的药代动力学及生物利用度  

The pharmacokinetics and relative bioavailability of r apid dissolving tablet of famotidine in mouth

作　　者：ZHANG Jian-chun 张建春[2] 邓明德[2] 陈鼎继[2] 蒋雪涛[3] 

机构地区：[1]The First Hospital of PLA,,兰州730030 [2]解放军第一医院,,上海200433 [3]第二军医大学药学院,

出　　处：《中国新药杂志》2001年第3期198-200,共3页Chinese Journal of New Drugs

摘　　要：目的：研究法莫替丁口溶片在家兔体内的药代动力学过程和生物利用度。方法：家兔单剂量服用法莫替丁口溶片和法莫替丁普通市售片后，用高效液相色谱法测定血药浓度。结果:法莫替丁口溶片和普通市售片的AUC分别为(2 687.63±461.65)和(1 477.65±484.28)(ng*h)/ml,C max为(658.18±84.97) 和(202.80±57.29) ng/ml,Tmax为(1.29±0.23)和(2.85 ±0.54)h。结论:口溶片与普通片AUC的差异有统计学意义(P<0.0 1),相对生物利用度为181.88%。Objective:To study the pharmacokinetics and bioavailability of rapid dissolving tablet of famotidine in mouth and famotidine market tablet in rabbits.Methods:Rapid dissolving tablets in mouth and market tablets of famotidine were single dose orally given to rabbits.The blood levels of famotidine was determined by HPLC method.Results:The AUC,C max and T max of rapid dissolving tablets in mouth of famotidine were (2 687.63±461.65)(ng·h)/ml,(658.18±84.97)ng/ml and (1.29± 0.23)h,and the AUC,C max and T max of market tablet of famotidine were (1 477.65± 484.28) (ng·h)/ml, (202.80±57.29) ng/ml and (2.85±0.54)h.Conclusion:There is significant difference ( P < 0.01) between the AUC of two products,and the bioavailability of rapid dissolving tablet of famotidine in mouth is 181.88%. [

关 键 词：法莫丁 口溶片 高效液相色谱法 生物利用度 药代动力学 

分 类 号：R975.6[医药卫生—药品]