3种抗癫痫药的血药浓度监测及个体化用药体会  

Depermination of the Serum Concentrations of Three Kinds of Antiepileptic Drugs and the Experience of Individualized Drug Administration

作　　者：李红健[1] 冉国侠[1] 曹丽蒙[1] 吴建华[1] 

机构地区：[1]新疆自治区人民医院药剂科,乌鲁木齐市830001

出　　处：《中国药房》2001年第3期160-161,共2页China Pharmacy

摘　　要：目的 :为临床抗癫痫药的合理应用提供参考。方法 :采用荧光偏振免疫法对88例服用苯妥英钠、63例服用苯巴比妥和63例服用卡马西平的患者进行血药浓度监测242次 ,并提供个体化给药方案。结果 :癫痫患者对这3种抗癫痫药的敏感性个体差异很大。结论 :癫痫患者的个体化用药必须以血药浓度数据为依据 。AIM:To give some information for rational administration of oral antiepileptic drugs to epileptic patients in clinic METHODS:The serum concentrations of oral phenytoin sodium,phenobarbital and carbamazepine were determined in 88,63 and 63 epileptic patients(total 214 times)by fluorescence polarization immunoassay,respectively The individualized drugs administration schemes were provided RESULTS:The sensitivity to the three kinds of antiepileptic drugs varied in different patients CONCLUSIONS:The administration of oral antiepileptic drugs to epileptic patients must be based on the data of drug concentration in serum We must comprehensively consider the other factors

关 键 词：苯妥英钠 苯巴比妥 卡马西平 血药浓度监测 个体化给药 抗癫痫药 

分 类 号：R971.6[医药卫生—药品]