旱柳叶中3种化学成分的药理活性研究  

Studies on Pharmacology of Chemical Constituents of Leaves of Salix matsudana

作　　者：张晶[1] 郑毅男[1] 韩立坤[2] 张新凤[1] 

机构地区：[1]吉林农业大学中药材学院,长春130118 [2]日本爱媛大学医学部,日本国松山市79102

出　　处：《吉林农业大学学报》2001年第1期54-57,共4页Journal of Jilin Agricultural University

基　　金：吉林省科委资助项目! (吉科合字第 95 0 0 0 2号 )

摘　　要：对自旱柳叶中分离出的 3种单体化合物进行了药理活性研究 ,测定它们对花生四烯酸代谢及其对脂肪细胞脂肪分解活性的影响 ,结果发现 :它们均可选择性抑制花生四烯酸代谢产物 12 HETE的生成量 ,预示它们可防治动脉硬化及过敏症 ;芹黄素 7 O β D 吡喃葡萄糖醛酸苷水解后的苷元———芹黄素可抑制TXB2 的生成量 ,提示其对血栓的形成有防治功效。它们对正常大鼠附睾处脂肪细胞由去甲肾上腺素 (NE)诱导的脂肪分解作用的影响结果表明 :此Effects of three compounds isolated from the leaves of Salix matsudana on arachidonic acid metabolism and norepinephrine-induced lipolysis in rat platelets were studied. The result showed that these compounds could selectively inhibit the yield of arachidonic acid metabolism's production—12-HETE (12-hydroxy-5,8,10,14-eicosatetraenoic acid), indicating that they could prevent and cure allergy and arteriosclerosis. The production of apigenin-7-O-β-D-glucopyranside being hydrolyzed was apigenin, it could inhibit the yield of TXB 2 (thromboxane B 2).The result of effect on NE-induced lipolysis of fat cells in normal rat′s testicle showed that they can promote lipolysis.

关 键 词：花生四烯酸 脂类分解 旱柳叶 化学成分 药理活性 

分 类 号：R284.1[医药卫生—中药学]