臭一叶秋碱与一叶秋碱的一般药理学作用比较  

Pharmacological Comparison between Virosecurinine and Securinine

作　　者：蒲含林[1] 赵金华[2] 彭波[2] 许实波[2] 

机构地区：[1]暨南大学生物工程研究所,广州510632 [2]中山大学生命科学学院

出　　处：《中药材》2001年第4期278-280,共3页Journal of Chinese Medicinal Materials

摘　　要：比较研究臭一叶秋碱与其对映异构体一叶秋碱的药理活性,发现臭一叶秋碱的毒性为一叶秋碱的1/13.6,且无一叶秋碱的致惊厥作用,两者均有一定的心血管及呼吸兴奋作用。Pharmacological activities of virosecurinine (Vse) and securinine (Sec) were studied. The results showed that acute toxicity of Vse was 1/13.6 that of Sec,and Vse had no convulsive eifects on rats or frogs, while Sec had. The results also showed that Vse and Sec could elevate blood pressure and excite respiration in cats.

关 键 词：臭一叶秋碱 一叶秋碱 惊厥 自主活动 血压 呼吸 药理学 

分 类 号：R282.71[医药卫生—中药学]