3156例原发性高血压脂肪分布与大动脉缓冲功能关系研究  

Analysis of Relationship between Fat Distribution and Large Arterial Buffering Function in 3 156 Essential Hypertensive Patients

作　　者：倪永斌[1] 张维忠[1] 王宏宇[2] 吴美枝[1] 

机构地区：[1]上海第二医科大学附属瑞金医院上海市高血压研究所心功能室,上海市200025 [2]北京大学人民医院心内科北京市

出　　处：《中国循环杂志》2001年第2期106-108,共3页Chinese Circulation Journal

摘　　要：目的：研究肥胖和局部体脂分布与原发性高血压患者大动脉缓冲功能的关系。 方法：对３ １５６例原发性高血压患者分别测量血压、身高、体重、腰围和臀围，根据体重指数将其分为非超重组、超重组和肥胖组，并按腰臀围比值分为中心胜肥胖组和非中心胜肥胖组，应用法国产自动脉搏波速度测定仪Ｃｏｍｐｌｉｏｒ测量颈动脉－股动脉脉搏波速度，分析比较体重指数和腰臀围比值（≥０．９５者认为是中心性肥胖）与脉搏波速度的关系。 结果：体重指数和脉搏波速度不相关，而女性腰臀围比值和脉搏波速度呈正相关（ｒ＝０．２２０，Ｐ＜０．０００１）。女性中心性肥胖组脉搏波速度明显高于非中心性肥胖组，有极显著差异（１１．９６ ｍ／ｓ ｖｓ．１１．０６ ｍ／ｓ，Ｐ＜０．００１），在校正年龄、身高、收缩压、心率、体重指数和脉压等影响因素后，两组间仍有极显著差异（１１．６１ｍ／ｓ ｖｓ． １１．２４ ｍ／ｓ，Ｐ＜０．０１）。但男性两组间无明显差别。 结论：女性原发性高血压患者中心性肥胖是影响大动脉缓冲功能的重要因素。Objective: To investigate the relationship between obesity and regional body fat distribution and large artery buffering function in patients with essential hypertension. Methods: Blood pressure, height, weight, waist circumference, hip circumference and carotid-femoral pulse wave velocity (Complior,France) were determined respectively in 3 156 essential hypertensive patients and the relationship between body mass index,waist-hip ratio(≥０.95 was defined as central obesity) and pulse wave velocity was analyzed. Results:Body mass index was not related to pulse wave velocity,while in female waist-hip ratio and pulse wave velocity were significantly correlated(r ＝ 0. 220, p<0. 0001 ). Compared with noncentral obesity, pulse wave velocity of central obesity was significantly greater (11. 96 m/s vs. 11. 06 m/s,p＜0. 001),even after adjusted for the confounding factors(including age, height, systolic blood pressure, heart rate, body mass index and pulse pressure) (11. 61 m/s vs. 11. 24 m/s,p<0. 01). However,there was not significant difference between the two groups in male. Conclusion:Central obesity is an important factor that influences large arterial buffering function in female patients with essential hypertension.

关 键 词：原发性高血压 腰臀围比值 脉搏波速度 脂肪分布 

分 类 号：R544.1[医药卫生—心血管疾病]