补阳还五汤提取物对脑缺血再灌流后一氧化氮合酶活性的影响  

Influences of Buyanghuanwu Decoction Extract on nitric oxide synthase activity in cerebral ischemic reperfusion damage in rats

作　　者：毛小平[1] 陈秀芳[1] 张玲[1] 李丽仕 

机构地区：[1]武汉大学人民医院神经内科 [2]武汉空军95096部队卫生队

出　　处：《卒中与神经疾病》2001年第2期103-104,共2页Stroke and Nervous Diseases

摘　　要：目的　观察补阳还五汤提取物 (BDE)对脑缺血再灌流后一氧化氮合酶 (NOS)活性的影响。方法　建立大鼠大脑中动脉栓塞 (MCAO)及再灌流模型 ,利用NADPH d组织化学方法检测大脑皮质神经元内NOS活性。结果　BDE组NOS活性与对照组比较 ,有显著性差异 (P <0 .0 5 )。结论　BDE抑制神经元NOS活性 ,对脑缺血再灌流损伤具有脑保护作用。Objective To observe the effects of Buyanghuanwu Decoction Extract (BDE) on nitric oxide synthase (NOS) activity in cerebral ischemic reperfusion damage. Methods Rat models of middle cerebral artery occlusion (MCAO) and reperfusion was established. NADPH d histochemical technique was used to investigate the activity of NOS in cortical neurons. Results The results showed that the activity of NOS in BDE group was significantly decreased compared with cerebral ischemic reperfusion group ( P < 0.05 ). Conclusion BDE may have protect effect on cerebral ischemic reperfusion damage by decreasing Nos activity.

关 键 词：脑缺血再灌流损伤 一氧化氮合酶 补阳还五汤提取物 

分 类 号：R277.733[医药卫生—中医学] R743.3