蒙药广枣总黄酮对大鼠离体心脏的抗心律失常作用  

Antiarrhythmic action of total flavones of Choetospondias axillaries fructus in rat heart in vitro

作　　者：徐继辉[1] 杨玉梅[1] 覃建民[1] 许翠英[1] 李增曦[1] 周长风 冯国庆 白音夫 宋一亭 

机构地区：[1]内蒙古包头医学院,014010 [2]内蒙古中蒙医研究所,010020

出　　处：《中国民族医药杂志》2001年第2期25-26,共2页Journal of Medicine and Pharmacy of Chinese Minorities

基　　金：国家自然科学基金资助!(3976 0 0 83)

摘　　要：本文采用 Langendouff灌流法观察广枣总黄酮 ( TFC)抗心律失常的作用机制。结果表明 ,TFC可明显对抗大鼠离体心脏缺氧性心律失常 ,显著延长心律失常出现时间 ,明显降低心律失常和心脏停搏发生率。TFC可显著提高心脏室颤阈值 ,并呈良好量效和时效关系。结果提示 ,TFC的抗心律失常作用与提高心肌电稳定性 ,降低心室易颤性有关。Objective:To research the mechanism of antiarrhythmic action of Fructus Choetospondias by Langendorff method.(TFC).Methods:The isolated perfused rat hearts were used.Result:TFC counteracted significantly the arrhythmia caused by perfusing with an anoxic solution ,prolonged markedly arrhythmia apperance time,decreased evidently the frequency of arrhythmia and the cardiac arrest.TFC also increased ventricular fibrillation threshold markedly and showed a good dose-effect and time-effect relation.Conclusion:The antiarrhythmic action of TFC is related to the increase of stability of myocardium and decrease of susceptibility to ventricular fibrillation.

关 键 词：广枣总黄酮 利多卡因 室颤阈值 抗心律失常药 心律失常 药理 蒙药 

分 类 号：R291.2[医药卫生—民族医学] R259.417[医药卫生—中医学]