蛇葡萄根对ConA诱导小鼠肝损伤模型Fas抗原表达的影响  

Effects of Ampelopsis Brevipedunculata Trautv on Fas Antigen Expression in Liver Tissue of Micc Liver Injury Models Induced by Concanavalin A(ConA)

作　　者：张赤志[1] 李之清[1] 张亚兵[2] 

机构地区：[1]湖北中医学院肝病研究所,武汉430061 [2]武汉大学中南医院中医科,武汉430070

出　　处：《中国中西医结合脾胃杂志》2001年第2期67-68,70,共3页

基　　金：湖北省自然科学基金资助项目 (No.96 J0 99)

摘　　要：目的 :探讨蛇葡萄根对刀豆蛋白 A (Con A)诱导小鼠肝损伤模型肝组织 Fas抗原表达的影响。方法 :采用Con A诱导建立小鼠肝损伤模型 ,与地塞米松对照 ,观察蛇葡萄根高、中、低剂量组对小鼠肝脏病理变化和肝组织中Fas抗原表达的影响。结果 :蛇葡萄根高、中剂量组可减轻肝脏病理变化 ,减少肝细胞 Fas抗原表达 ,与地塞米松组比较差异无显著性意义。结论 :蛇葡萄根可通过抑制肝细胞 Fas抗原表达来阻断肝细胞凋亡的发生。Objective:To investigate the effects of Ampelopsis Brevipedunculate Trautv of Fas antigen expression in liver tissue of mice liver injury models induced by Con A.Metheods:Liver injury models were induced by ConA in mice in vivo and treated with high,medium,low dosage Ampelopsis Brevipedunculate Trautv or Dexamethasone.Histopathological changes of the liver samples were obsrved.Results:High and medium dosage Ampelopsis Brevipedunculata Trautv alleviated the histopathological changes and decreased Fas antigen expression in liver tissue,and had no different from Dexamethasone used as control.Conclusion:Ampelopsis Brevipeduncluata Trautv restrain hepatocyte apoptosis by decreasing hepatocyte Fas antigen expression.

关 键 词：蛇葡萄根 刀豆蛋白A FAS抗原 中药 药理 

分 类 号：R282.710.5[医药卫生—中药学] R285.5[医药卫生—中医学]