新生儿溶血与HPVB_(19)感染的关系探讨  

STUDY ON RELATIONSHIP BETWEEN HPVB_(19) INFECTION ANDHEMOLYSIS NEONATORUM

作　　者：杨健[1] 陈晓丹[2] 黄月梅[1] 陈星群[2] 王丹妹[2] 

机构地区：[1]海南医学院附属医院儿科,海口570102 [2]海南医学院附属医院检验科,海口570102

出　　处：《海南医学院学报》2001年第1期11-13,共3页Journal of Hainan Medical University

基　　金：海南省教育厅科研资助项目!(No.99025)

摘　　要：目的:用红细胞破坏增多和红细胞生成增多的实验检查证实HPVB19 感染引起新生儿溶血。方法 :对45例用PCR方法确诊为HPVB19 感染 (已除外ABO血型不合、Rh阳性、G -6PD酶缺陷症、地中海贫血、败血症、弓形虫、单纯疱疹病毒、风疹病毒、CMV及乙肝病毒等感染 )的新生儿病理性黄疸患儿进行结合珠蛋白 (Hp-Hb)、游离血红蛋白、间接胆红素、直接胆红素、在不同程度上血红蛋白 (Hb)、尿胆元及网织红细胞检查。结果 :45例HPVB19 感染患儿均存在红细胞破坏增多和红细胞生成增多的证据。结论 :在新生儿溶血性黄疸患儿中存在HPVB19Objective:To confirm whether HPVB19 infection to be the cause of hemolytic jaundice of the newborn by means of increasing both erythrocytolysis and erythrocytopoiesis tests.Method: 45 newborn cases of hemolytic jaundice with HPVB19 infection were diagnosed by PCR and excluded to be incompatible ABO blood group, Rh positive, G6PD deficiency, thalassimia, septemia, toxoplasmosis, HSV, NRV, CMV and HBV . Heptoglobin, free Hb, indirect and direct reacting bilirubin, urobilinogen and reticulated erythrocytes in blood were examined for the newborn cases. Results: The evidences of both erythrocytolysis and erythrocytopoiesis increases were found in all cases of the newborn with HPVB19 infection. Conclusion: The newborn suffering hemolytic jaundice have HPVB19 infection.

关 键 词：HPVB19 微病毒属 溶血性贫血 婴儿 新生儿溶血 

分 类 号：R722.18[医药卫生—儿科] R725.566[医药卫生—临床医学]