热缺血对兔肾表面微循环的影响  

Effect of warm ischemia on the renal subcapsular microcirculation

作　　者：乔保平[1] 赵明堂[1] 魏金星[1] 陈勇夫 高延昭[3] 于定国 

机构地区：[1]河南医科大学第一附属医院泌尿外科 [2]河南医科大学生物学教研室 [3]河南医科大学病理解剖学教研室 [4]河南医科大学修配厂

出　　处：《河南医科大学学报》1991年第1期20-24,共5页Journal of Henan Medical University

摘　　要：作者用10只家兔.观察了不同时限热缺血对兔肾表面微循环的影响。将动物分四组。A组为手术对照,不阻断肾动脉。其余B、C、D组分别阻断左肾血流10min、30min和60min。在阻断前和恢复血流10min后,分别用显微镜观察肾表面微循环。行右肾切除。动物观察14天。结果表明,10min缺血组动物仅有轻度毛细血管收缩。30min以上热缺血.不仅引起更明显的微血管收缩,还可引起不同程度的血管扩张和血流淤滞现象。微循环紊乱尤其是血流淤滞的程度.与术后肾功能及组织学检查结果一致。提示缺血后肾皮质微循环状况与肾功能恢复密切相关。肾保存时,保存液中加入适当保护剂保护肾脏微循环,对于移植后肾功能的恢复具有重要意义。The effect of warm ischemia on renal subcapsular microcirculation was studi-ed in 40 rabbits. All rabbits were assigned to four groups at random. Group A wassham-operated without clamping the pedicle. The left renal artery of group B,C and D was occluded for 10, 30 and 60min respectively. The renal subcapsularmicrocirculation was observed with microscope before clamping and 10min afterunclamping. Then the right nephrectomy was performed and the rabbits were obs-erved for 14 days. The result showed that there was only mild vasoconstriction ofrenal subcapsular capillary vessels in the animal subjected to 10min of warm isc-hemia. Afer 30min or more ischemia, not only severe constriction but also vasodi-lation and intravascular erythrocyte sludging occurred in the animal. The severityof the disorder, especially intravascular erythrocyte aggregation, were correlatedwell with the postoperative renal function and the results of histological examina-tion. The data suggest that efforts to maintain the integrity of the renal micro-circulation be the key prerequisite to the immediate renal function after transpla-ntation. Measures designed to protect the renal microcirculation during renal pres-ervation may be imprortant in improving current results of renal transplantation.

关 键 词：热缺血 肾表面 微循环 肾移植 

分 类 号：R699.202[医药卫生—泌尿科学]