赤芍总苷对大鼠皮层神经细胞钙超载损伤的保护作用  

Protective Effect of Total Peaony Glycoside on Calium-Overloading Injury of Nerve Cells in Rat Cortex

作　　者：何丽娜[1] 何素冰 江怡[2] 杨军[1] 

机构地区：[1]安徽省医学科学研究所省生物医药重点实验室,合肥230061 [2]合肥市第二人民医院,合肥230011

出　　处：《中药新药与临床药理》2001年第3期212-215,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的 :探讨赤芍总苷对大鼠神经细胞钙超载损伤模型的保护作用及其机制。方法 :采用组织培养法 ,以原代大鼠大脑皮层神经细胞为材料 ,制备Caf、KCl及NMDA诱导的钙超载损伤模型。结果 :赤芍总苷对 3种钙超载损伤模型大鼠神经细胞均具有明显保护作用 ,可显著提高损伤模型神经细胞的存活数并降低细胞释放LDH的水平。结论 :赤芍总苷对钙超载所致大鼠神经细胞损伤有显著的保护作用。Objective: To investigate the protective effect and mechanism of total peaony glycoside (TPG) on calium overloading injury of nerve cells in rat models. Methods: The nerve cells of cerebral cortex of primary rats were subject to tissue culture,and the calcuim-overloading injury models were induced by caffeine,KCl and NMDA respectively. Results:TPG possessed obvious protective effects on the nerve cells in rat models, increased the number of survival nerve cells and reduced the content of LDH released nerve cells.Conclusion: TPG can protect rat nerve cells with calium-overloading injuriy.

关 键 词：神经元 药物作用 赤芍总苷 药理学 神经元 钙超载损伤 化学诱导 疾病模型 

分 类 号：R282.710.5[医药卫生—中药学] R285.5[医药卫生—中医学]