不同含铁粉尘的细胞毒性作用研究 Ⅱ.含铁粉尘对肺泡巨噬细胞的毒性实验  

Study on Cytotoxisity of Different Dusts-containing Iron Ⅱ.Study on Cytotoxicity of Dusts-containing Iron to Alveolar Macrophage

作　　者：陈丹[1] 陈宁蒙[1] 邹昌淇 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所

出　　处：《卫生研究》1991年第6期1-3,共3页Journal of Hygiene Research

摘　　要：本文观察了三种含铁粉尘（纯氧化铁尘，电焊烟尘和铁锈尘）对体外加尘培养的肺泡巨噬细胞（AM）的毒性作用，以AM存活率及其光镜和扫描电镜的形态学变化作为观察指标，结果表明，三种含铁粉尘均能引起不同程度的AM毒性作用，其中铁锈尘和电焊烟尘引起AM存活率下降及形态改变较纯氧化铁尘明显，高浓度的纯氧化铁尘亦可引起轻度的AM损伤。In this paper, three kinds of dusts-containing iron(pure iron oxide,welding fume and iron rust) were evaluated for their cytotoxicity to alvoelar macrophage( AM) cultured in vitro. The measured cytotoxicity parameters were: cell viability, cell morphological changes with Light Microscopy( LM) and Scanning Electric Microscopy( SEM). The results showed that all three kinds of dusts-containing iron could induce the different degrees of cytotoxicity to AM. Among them, the decrease of cell viability and morphological changes of welding fume and iron rust were more obvious than those of pure iron oxide. Pure iron oxide also induced slight injury of AM in the high dust concentration.

关 键 词：含铁粉尘 巨噬细胞 细胞毒性 

分 类 号：R135.2[医药卫生—劳动卫生]