高血压患者红细胞Na^+/Mg^(2+)交换速率与胰岛素抵抗相关研究  

Study on the correlation between erythrocyte Na^+/Mg^(2+) exchange rate and insulin resistance in patients with essential hypertension

作　　者：袁林 李培[2] 苗蓁蓁 赵萍 朱成章 曾红 周兢业[3] 尹祚莹[3] 

机构地区：[1]贵阳市第二人民医院,贵州省贵阳市550002 [2]贵阳医学院老研所 [3]中国科学院地球化学研究所

出　　处：《心血管康复医学杂志》2001年第2期100-103,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：贵阳市科委自然基金

摘　　要：目的 :探讨原发性高血压 (EH)、脑出血 (CH)、脑梗死 (CI)患者血浆和红细胞镁、钠水平 ,及红细胞镁 /钠交换速率与胰岛素抵抗 (IR)的相关性。方法 :用原子吸收光谱火焰法测定 2 3例 EH、 2 1例 CH和 34例 CI急慢性患者及 2 0例正常对照组的血浆和红细胞镁、钠水平。以红细胞加镁负荷试验测定总镁外流最大速率 (VTmax)钠依赖与非依赖性镁外流最大速率 ,并按 ISI法评定胰岛素抵抗。结果 :与对照组相比 ,EH组红细胞镁含量 (EMC)明显减少 (P <0 .0 5 ) ,钠依赖性镁外流最大速率 (VNDmax)、VTmax明显加快 (P<0 .0 5 ) ;CH、CI急慢性期组患者 EMC减少非常显著 (P<0 .0 5～ 0 .0 0 1) ,红细胞钠含量 (ENC)增加非常显著 (P<0 .0 5～ 0 .0 1) ,VNDmax、 VTmax加快非常显著 (P<0 .0 5～ 0 .0 1)。ISI与 EMC、VNDmax呈负相关 ,与 ENC呈正相关。结论 :EH,特别是脑卒中患者 EMC显著增加 ,ENC显著减少。它可能参与了胰岛素抵抗的发生和发展 ,,从而影响动脉粥样硬化过程。Objective:To investigate the plasma sodium(PNa) 、magnesium (PMg) levels, erythrocyte sodium content (ENC)、magnesium content(EMC) , erythrocyte Na +/Mg 2+ exchange rate and its correlation with insulin resistance(IR) in patients with essential hypertension(EH), cerebral hemorrhage(CH), cerebral infarction(CI).Methods:PNa、PMg, 、ENC、EMC and Na +/Mg 2+ exchange rate were measured by flame assay of atomic absorption spectrophotometer. Total magnesium efflux(V Tmax ), sodium\|dependent magnesium efflux(V NDmax ) were measured by supplying magnesium test. IR was evaluated by ISI method.Results: Compared with control group, EMC decreased ( P <0 05), V Tmax 、V NDmax accelerated( P <0 05) in EH group;EMC significantly decreased ( P <0 05～0 001), ENC significantly increased ( P <0 05～0 01),V Tmax 、V NDmax significantly accelerated( P <0 05～0 001) in CH、CI group. There were significantly negative correlation( P <0 05～0 01) among ISI and EMC、V NDmax ,and there was significantly positive correlation( P <0 05～0 01) between ISI and ENC. Conclusion:EMC decrease, V Tmax 、V NDmax accelerate in EH group, particularly in stroke. It may take part in happen of IR and influence process of atherosclerosis.

关 键 词：高血压 脑卒中 镁 离子交换 胰岛素抵抗 

分 类 号：R544.1[医药卫生—心血管疾病]