硝苯地平长效与短效制剂对高血压患者生活质量的作用比较  

The Effects of Nifedipine GITS and Nifedipine on the Quality of Life in Hypertensive Patients during Antihypertensive Therapy

作　　者：王健生[1] 金雪娟[1] 徐伟[1] 时智英[1] 陈灏珠[1] 

机构地区：[1]复旦大学附属中山医院,上海市心血管病研究所上海200032

出　　处：《中国临床医学》2001年第2期117-119,共3页Chinese Journal of Clinical Medicine

摘　　要：目的 :探讨二氢吡啶类钙通道阻滞剂硝苯地平的长效制剂拜新同 (nifedipineGITS ,硝苯地平控释片 )与短效制剂心痛定(nifedipine ,硝苯地平 )对轻中度高血压患者治疗作用与生活质量的影响。方法 :两周停药”冲洗期”后 ,12 0例轻中度高血压病人 (舒张压 95～ 114mmHg)被随机分配到拜新同组 (口服 30mg ,每日 1次 )或心痛定组 (口服 10mg ,每日 3次 ) ,疗程共 3个月 ,治疗前后分别记录血压和填写生活质量量表。评价治疗前与治疗 3个月后生活质量的改变。结果 :降压疗效两组没有显著差别 ,血压下降拜新同组为 15 / 13mmHg ,心痛定组为 16 / 12mmHg(P >0 .0 5 ) ;两组不良反应也无显著差别 ;拜新同组生活质量三个分量表得分均有明显改善 ,心痛定组躯体功能与心理健康得到改善 ,社会功能分量表质量下降 ,但无显著差别。结论 :拜新同与心痛定降压治疗安全、有效 ,可改善患者的生活质量 ,两者比较拜新同优于心痛定 ,为一种比较理想的降压药物。Objective: This study aimed to explore the effects of nifedipine GITS and nifedipine on the quality of life during antihypertensive therapy among patients with mild to moderate hypertension. Methods: A randomized clinical trial was conducted and 120 patients with mild to moderate hypertension were received nifedipine GITS (30mg/day, qd) or nifedipine (10mg/day ,tid) for 3 months follow up. Quality of life data were assessed at the beginning and end of active therapy with questionnaire. Results: 1.There were no significant differences between the two groups in the blood pressure changes(nifedipine GITS -15/13mmHg,nifedipine -16/12 mmHg). 2. There were no significant difference between the two groups in adverse events. 3. The nifedipine GITS group improved quality of life in all. 4. Nifedipine groups showed a slight improvement in quality of life.Conclusion: Both nifedipine GITS and nifedipine are safe and effective for antihypertensive therapy but the former is better than the latter as a kind of proper antihypertensive drug.

关 键 词：生活质量 高血压 硝苯地平 药物治疗 长效制剂 短效制剂 

分 类 号：R544.1[医药卫生—心血管疾病]