复合人工骨修复股骨头骨缺损的影像学研究  

A scintigraphic study of composited bone substitute in the repair of bone defect of femoral head

作　　者：同志勤[1] 徐小良[2] 王坤正[2] 宋厂义[1] 

机构地区：[1]西安交通大学第二医院影像中心,西安710004 [2]西安交通大学第二医院骨科,西安710004

出　　处：《西安医科大学学报》2001年第2期135-137,150,共4页Journal of Xi'an Medical University(Chinese)

基　　金：陕西省自然科学资金资助! (99sm6 0 )

摘　　要：目的　研究用复合人工骨治疗股骨头坏死的效果。方法　建立双侧股骨头内骨缺损模型 ,并分为 4组 :bBMP 胶原 珊瑚复合人工骨组 (5侧 )、肌骨瓣组 (5侧 )、单纯珊瑚组 (4侧 )、对照组 (1 4侧 ,为以上各组的对侧 )。造模及植入后定时行X线、核素骨显像、MRI及CT检查。结果　①核素骨显像示 :6周及 1 2周 ,Ⅰ组股骨头核素摄取量静态相头 /干比升高 ,但血流相及血池相不升高。②MRI:1 0周示Ⅰ组骨缺损内多量新生骨形成 ,Ⅳ组骨缺损内囊腔中为脂肪性信号 ,周围为低信号的硬化带。③拍片及CT示 :1 4～ 1 6周 ,Ⅰ组骨缺损大多完全闭合 ,珊瑚已吸收 ,其余各组骨缺损部分残留 ,Ⅳ组骨缺损囊壁硬化带形成。结论　该复合人工骨有较强的传导成骨及诱导成骨作用 ,是修复股骨头骨缺损的良好移植材料 ,但它不能改善缺血坏死股骨头的血供。Objective To evaluate the effect of bBMP collagen coral composited bone substitute in treatment of osteonecrosis of the femoral head(ONFH). Methods Canine bone defect of bilateral femoral head was established,They were devided into 4 groups:Ⅰ.composited bone substitute group( n =5),Ⅱ.muscle pedicle bone group ( n =5),Ⅲ.simple coral group( n =4),Ⅳ.control group:contralateral hip( n =14).Roentgenography,Scintigraphy,MRI,CT were examined and studied at various time.Results ①Scintigraphic changes:In group Ⅰ,static bone image showed increased radionuclide uptake,but blood flow and blood pool image didn't show in 6 and 12 week;②MRI:There was much more new bone formation in the bone defect of group Ⅰ;In group Ⅳ,there was fatty bone marrow which was surrounded with sclerotic bone;③Resules of roentgenographic and CT:In 14 16 weeks,in group Ⅰ,the coral was absorbed and most of the bone defects were closed completely;In the rest groups,part of each bone defect was remained except that in group Ⅳ,cystic sclerosis was formed.Conclusion The composited bone substitute possesses a superior osteoinductivity and osteoconductivity in the repair of bone defect of femoral head,but it can't improve the revascularization of ONFH.

关 键 词：股骨头坏死 骨缺损 骨形态发生蛋白 人工骨 影像学 

分 类 号：R681.8[医药卫生—骨科学] R683[医药卫生—外科学]