早产病人血C-反应蛋白总补体活性补体成分3与亚临床绒毛膜羊膜炎的关系  

Relationship between serum CRP CH_ 50 C_ 3 concentration in premature labor and subclinical chorioamnionitis

作　　者：尹香花[1] 朴贞姬[1] 宋艳春 

机构地区：[1]延边大学医学院附属医院妇产科,延吉133000 [2]吉林省白山市三岔子林业局职工医院妇产科,134300

出　　处：《中国实用妇科与产科杂志》2001年第3期152-154,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　探讨早产病人血C -反应蛋白 (CRP)、总补体 (CH50 )活性、补体成分 3(C3)对亚临床感染的早期诊断价值。方法　应用双抗体夹心ELISA法测定CRP ,根据改良Mayer单管比色法、琼脂单向免疫扩散法分别测定CH50 、C3。结果　有亚临床绒毛膜羊膜炎的早产孕妇血清CRP明显高于正常妊娠妇女 (P <0 0 1) ,早产孕妇的亚临床绒毛膜羊膜炎越重 ,血清CRP相应增高。随着CRP含量的升高 ,CH50 及C3 含量相应降低。早产病人血CRP是现有指标中对亚临床绒毛膜羊膜炎反应最敏感的指标。结论　早产病人血CRP、CH50 、C3 是早期判定亚临床感染的一项简便、可靠。Objective To determine the early diagnostic value of serum C-reactive protein(CRP)、total complement(CH 50 ) activity and complement 3(C 3) concentration of premature women in the subclinical infection.Methods Solid phase enzyme linked immunosorbent assay (ELISA method) was used for measurements of serum CRP levels.According to modified Mayer simple tubular colorimetric method and simple agar immunodiffusion method,we determined the CH 50 、C 3 concentration respectively. Results Premature women with subclinical chorioamnionitis showed higher serum CRP concentration than that of normal pregnancy women(P<0 01).In the subclinical chorioamnionitis,the more serious the infection,the higher the CRP concentration,while CH 50 and C 3 concentrations were correspondently decreased.Serum CRP concentration in premature labor was the most sensitive index that suggested subclinical chorioamnionitis. Conclusions Serum CRP、CH 50 and C 3 concentrations in premature labor are simple,reliable and accurate indexes for early diagnosis of subclinical infection.

关 键 词：早产 绒毛膜羊膜炎 C-反应蛋白 总补体 补体成分3 

分 类 号：R714.21[医药卫生—妇产科学]