健骨冲剂对去卵巢大鼠骨组织形态计量学的影响  

Histomorphometric Study of the Effects if JianguChongji on the Bone Turnover in Ovariectomized Female Rats

作　　者：王晓达[1] 胡庆沈[2] 陈伟珍[1] 江兰英[2] 史炜镔[1] 张凤华[1] 符诗聪[1] 杜宁[1] 李国衡[1] 

机构地区：[1]上海第二医科大学附属瑞金医院伤科,上海市伤骨科研究所上海200025 [2]上海第二医科大学生物物理实验室

出　　处：《中国中医骨伤科杂志》2001年第2期17-20,共4页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：上海市科委资助!项目 编号 :9741190 3

摘　　要：目的 :评估健骨冲剂短期预防性应用对绝经后骨质疏松症的作用 ,并试图揭示其机理。方法 60只SD大鼠通过卵巢摘除术随机分为正常对照组 ( SHAM)、模型组、健骨冲剂高、中、低剂量组和仙灵骨葆组 ,治疗 1月后作骨组织形态计量学观测。结果 :健骨冲剂组 BV/TV、Tb.Th、骨小梁间距、节点数显著高于造模组 ,游离未端数显著少于后者 ;骨计量学指标低、高剂量组与仙灵骨葆无差别 ,中剂量组优于后者。结论 :健骨冲剂短期预防应用能够改善骨质疏松症模型大鼠的骨计量学指标 :增加最终形成骨量 ,改善骨小梁结构 ,提高骨形成速率的同时降低骨吸收速率。Objective:To assess the effects of Jiangu Chongji(JC) on preventing postmenopausal osteoporosis,attempt to reveal its mechanism.Methods:60 female Sprague Dawley rats at 6 months of age were chosen:they were randomly devided 6 groups,ovariectomized and treated for 1 month.Then Under VIDAS system,bone turnover was assessed by bone histomorphometry.Results:BV/TV,Tb.Th,Spacing,Junction increased and Nomadic Terminal decreased significantly in the groups fed on JC compared to model rats;there is no remarkable difference between low,high dose JC and Xianlinggubao,but BV/TV,Tb.Th,Junction in middle dose JC groups were significantly increased with the group fed X.Conclusion:JC can optimize parameteers of histomorphometry:increase bone mass,force bone stucture and accelerate bone form with deceleration in bone absorption in ovariectomized female rats.

关 键 词：健骨冲剂 骨质疏松 骨组织形态计量学 玄卵巢大鼠 中医药治疗 

分 类 号：R271.917.5[医药卫生—中西医结合] R285.5[医药卫生—中医妇科学]