心肌梗塞不同时期心肌Ⅰ、Ⅲ型胶原重建的研究  

Study on myocardial collagen Ⅰ, Ⅲ remodeling in different phases after myocardial infarction

作　　者：毛宇彬[1] 雷立权[2] 

机构地区：[1]厦门市中医院病理科,厦门361001 [2]西安交通大学医学院病理生理教研室,陕西西安710061

出　　处：《中国病理生理杂志》2001年第4期359-361,共3页Chinese Journal of Pathophysiology

摘　　要：目的 :对心肌梗塞不同时期心脏各部位胶原重建进行定性、定位、定量研究。方法 :应用免疫组化技术结合自动图象分析方法观察Ⅰ、Ⅲ型胶原分布及含量的变化。结果 :心肌梗塞后坏死区Ⅰ、Ⅲ型胶原含量及Ⅰ Ⅲ比值均增加 ,以Ⅰ型胶原为主 ,急性期胶原仍交织成网状 ,至恢复期坏死心肌全部被胶原取代 ,呈致密束状与心腔表面平行排列。室间隔 (未梗塞区 )两型胶原含量及比值均增加 ,急性期以Ⅲ型胶原增加明显 ,恢复期以Ⅰ型胶原增加为主。右室在急性期胶原含量无明显改变 ,恢复期变化同室间隔 ,也以Ⅰ型胶原为主。结论 :心肌梗塞后胶原重建 ,梗塞区呈修复性纤维化 ,非梗塞区呈反应性纤维化 ,右室纤维化较左室晚。AIM: To study the distribution, location and quantity of myocardial collagen(Col) in different phases after myocardial infarction(MI). METHODS: The method of immunohistochemical technique combined with automatic image analysis was used to investigate the changes of collagen Ⅰ and Ⅲ. RESULTS:Contents of Col Ⅰ, Col Ⅲ and the ratio of Ⅰ/Ⅲ were all increased in infarcted area (IA)after MI,and the increase of Col Ⅰ was higher, the collagen fibers still construct a network in acute phase, in chronic stage, all necrosis myocytes were replaced by collagen, the fibers were dense, and paralelled with cardiac cavity surface.In the septum,noninfarcted area, contents of collagen type Ⅰ and Ⅲ, the ratio of Ⅰ/Ⅲ were increased.In acute phase, the increase of type Ⅲ is dominant,with in chronic phase, type Ⅰ is. Right ventricle(RV) has no significant change in acute phase,untill chronic phase,it changed like septum,the increase in collgen is mainly type Ⅰ. CONCLUSION: The collgen remodeled after myocardial infarction were reparative fibrosis in IA phase, and reactive fibrosis in NIA phase. Remodeling occured later in RV than in septum.

关 键 词：心肌梗塞 心肌胶原 大鼠 Ⅰ型 Ⅲ型目的 

分 类 号：R542.22[医药卫生—心血管疾病]