碳核苷类似物的合成与生物活性  

Studies on the Syntheses of 3(DXylopyranosyl)pyridazine and 3(DXylopyranosyl)4,5dihydro1H6pyridazinone

作　　者：孙德群[1] 朱京 马灵台 张礼和 

机构地区：[1]中国科学院成都有机化学研究所,成都,610041)(北京医科大学药学院

出　　处：《高等学校化学学报》1999年第6期895-899,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：利用杂环金属盐法，通过呋喃碳核苷中间体，合成了哒嗪、哒嗪酮等碳核苷，讨论了反应机理；New Cnucleoside analogues were synthesized via the key intermediate 2(2,34triObenzoylDxylopyranosyl)furan. The stability of the and isomer was described. The conversion of the furan ring into pyridazine ring was performed by ClausonKaas method to give 3(Dxylopyranosyl)pyridazine and 3(Dxylopyranosyl4,5dihydro6(1H)pyridazinone.

关 键 词：呋喃碳核苷 哒嗪 哒嗪酮碳核苷 碳核苷类似物 合成 生物活性 抗肿瘤药物 

分 类 号：TQ463.5[化学工程—制药化工] R979.1[医药卫生—药品]