三苦味酸根·2,2'-二硫代二(N-氧化吡啶)合稀土(Ⅲ) 配合物的合成、表征及其抗肿瘤活性研究  

Synthesis, Characterization and Antitumor Research of Tripicrate (2,2'-dithiobis (Pyridine-N-oxide)) Rare Earth（Ⅲ） Complexes

作　　者：张永平[1] 范丽岩[2] 唐宁[2] 谭民裕[2] 

机构地区：[1]兰州医学院基础部,兰州730000 [2]兰州大学化学化工学院,兰州730000

出　　处：《无机化学学报》2001年第3期427-430,共4页Chinese Journal of Inorganic Chemistry

摘　　要：Six rare earth picrate complexes with 2, 2’ -dithiobis (pyridine-N- oxide ) (L ) have been synthesized. The ligand L acts only as an N-oxide oxygen donor. The complexes were characterized by elemental analysis, and IR, and antitumor activity of [La(pic),L]. EtOH, [Eu(pic),L]. EtOH and [Er(pic)3L]. EtOH complexes were tested with L12l0 and HL-60 cells, the preliminary results of in vitro test show that the inhibitory effects of the complexes were significantly greater than that of ligand. Eu (Ⅲ) complex to HL-60, La, Eu and Er complexes to L12l0 all exhibit significant cytotoxicity and have potential prospect to be further developed.Six rare earth picrate complexes with 2, 2' -dithiobis (pyridine-N- oxide ) (L ) have been synthesized. The ligand L acts only as an N-oxide oxygen donor. The complexes were characterized by elemental analysis, and IR, and antitumor activity of [La(pic),L]. EtOH, [Eu(pic),L]. EtOH and [Er(pic)3L]. EtOH complexes were tested with L12l0 and HL-60 cells, the preliminary results of in vitro test show that the inhibitory effects of the complexes were significantly greater than that of ligand. Eu (Ⅲ) complex to HL-60, La, Eu and Er complexes to L12l0 all exhibit significant cytotoxicity and have potential prospect to be further developed.

关 键 词：2 2′-二硫代二(N-氧化吡啶)苦味酸盐 合成 表征 稀土配合物 

分 类 号：TQ463.54[化学工程—制药化工] R979.1[医药卫生—药品]