酶催化脱保护方法及在生物有机化学中的应用  

Application of Enzymatic Deprotection Reactions to Bioorganic Chemistry

作　　者：陈忠周[1] 李艳梅[1] 赵刚[1] 赵玉芬[1] 

机构地区：[1]清华大学

出　　处：《有机化学》2001年第4期273-277,共5页Chinese Journal of Organic Chemistry

摘　　要：系统地介绍和评述了近年来氨基、羧基、巯基和羟基等基团的酶催化脱保护方法的进展.由于酶催化脱保护方法具有反应条件温和(中性,水溶液)、选择性和专一性高、副反应少等优点,故在多肽缀合物、糖等敏感多官能团化合物的研究中有很广阔的应用前景.Recent advances in enzymatic deprotection reactions of amino groups, carboxyl groups, thiol groups and hydroxyl groups are reviewed. Enzymatic deprotection techniques, which have the advantages of high selectivity, high specificity under mild conditions and in aqueous solutions, are being evaluated as potential methods for synthesizing the sensitive compounds such as peptide conjugates and carbohydrates.

关 键 词：酶催化脱保护方法 氨基 羧基 多肽缀合物 生物有机化学 官能团 保护 

分 类 号：Q5[生物学—生物化学] Q67