胆红素及其两亲衍生物的Langmuir-Blodgett膜研究  

Studies on Langmuir-Blodgett Films of Bilirubin and Its Amphiphilic Derivatives

作　　者：欧阳健明[1] 林伟汉[1] 黄春晓[1] 姚秀琼[1] 

机构地区：[1]暨南大学生命科学技术学院化学系,广州510632

出　　处：《高等学校化学学报》2001年第5期722-726,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金!重点项目 (批准号 :2 0 0 3 10 10 );吉林大学超分子谱学开放实验室基金资助

摘　　要：研究了亚相酸度和金属离子对胆红素 (1 )及其两个两亲衍生物胆红素二 (十八烷基 )酯 (2 )和胆红素二(十八烷基 )酰胺 (3 )的单分子膜和 LB膜性能的影响 .通过 π-A等温线、X射线光电子能谱、紫外 -可见光谱等方法 ,研究了它们在有序分子膜中的分子伸展及与金属离子的配位方式 .胆红素及其两亲衍生物与金属离子在有序分子膜中的配位 (生成 1∶ 1型配合物 )明显不同于其在本体溶液中的配位 (1∶ 1 ,1∶ 2或 2∶ 1型配合物 ) .小角 X射线衍射表明 1 ,2和 3形成双层膜间距分别为 2 .1 5,5.55和 5.65nm的 Y型Monolayer formation, LB film fabrication of bilirubin(1), its two kinds of amphiphilic derivatives, bilirubin dioctadecyl ester [B(COOC 18 H 37 ) 2, 2] and dioctadecyl bilirubinamide [B(CONHC 18 H 37 ) 2, 3] at an air water interface on subphases with different pH values and subphases containing different metal ions were investigated and compared with 1. Some information regarding the packing density in monolayers, molecular orientation and complexation by metal ions has been obtained by means of many physical measurements such as the π A isotherms, X ray photoelectron spectroscopy, UV visible spectroscopy and low angle X ray diffraction. At the air water interface the amphiphilic ligands with their complexing head groups in contact with the aqueous phase can form metal complexes with many metal ions present in the aqueous phase. The formation of ligand metal complexes leads to changes in the area per molecule and in the collapse pressure, as well as to changes in the XPS and UV visible absorption spectra of the monolayer assemblies. Low angle X ray diffraction indicates that the LB films of 1, 2 and 3 were Y type with bilayer spacing of ca . 2.50, 5.60 and 5.65 nm. The coordination in ordered molecular films are much different from that in bulk solution. It can help us to understand the formation and prevent and cure of gallstones.

关 键 词：单分子膜 LANGMUIR-BLODGETT膜 胆红素 酸度 配位 胆红素 二(十八烷基)酯 胆红素二(十八烷基)酰胺 

分 类 号：O484[理学—固体物理]