阿苯达唑与氯冉酸的荷移反应与应用  

Application of Charge Transfer Reaction Between Albendazole and Chloranilic Acid

作　　者：赵桂芝[1] 李华侃[1] 柳越[1] 王玉华[1] 

机构地区：[1]锦州医学院化学教研室,锦州121000

出　　处：《分析化学》2001年第4期400-402,共3页Chinese Journal of Analytical Chemistry

摘　　要：研究并确定了阿苯达唑与氯冉酸的荷移反应条件。在乙醇丙酮介质中形成１∶１络合物，其λｍａｘ＝５２５　ｎｍ，吸光度与阿苯达唑浓度在０～２８０　ｍｇ／Ｌ范围内呈线性关系；表观摩尔吸光系数为８．０３×１０３Ｌ·ｍｏｌ－１·ｃｍ－１；桑德尔灵敏度为０．０３３　μｇ·ｃｍ－２；相对标准偏差小于１％（ｎ＝８），回收率符合要求。The charge transfer reaction between albendazole and chloranilic acid in alcohol-acetone solution was studied spectrophotometrically. The apparent molar absorptivity is 8.03 x 10(3) L.mol(-1).cm(-1) fat 525 nm. The Beer's law was obeyed in the range of 0 similar to 280 mg/L of albendazode. The composition of complex is 1:1. The proposed method was applied to the determination of albendazole tablets with satisfactory results.

关 键 词：荷移反应 阿苯达唑 氯冉酸 驱虫药 药物分析 分光光度法 

分 类 号：TQ460[化学工程—制药化工]