克林霉素磷酸酯注射液的分光光度法测定  

Spectrophotometric determination of clindamycin phosphate injection

作　　者：刘梅[1] 李祚宏[1] 贺建荣[1] 周瑾[1] 程建峰[1] 

机构地区：[1]第四军医大学唐都医院,陕西西安710038

出　　处：《中国医院药学杂志》2001年第5期273-274,共2页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :建立克林霉素磷酸酯注射液的含量测定方法。方法 :采用分光光度法于 5 2 0nm波长处测定克林霉素磷酸酯含量。结果 :线性范围 0 .10～ 0 .4 0mg·ml-1,r=0 .9999,平均回收率为 99.8% ,RSD为 0 .6%。结论 :方法简便、准确、快速 ,与HPLC法相比较两者并无显著性差异。OBJECTIVE To establish a quantitative method for clindamycin phosphate injection.METHODS The content of clindamycin phosphate injection was determined at 520 nm by spectrophotometry.RESULTS The calibration curve was linear in the range of 0.10 ～ 0.40 mg﹒ml -1 (r= 0.9999 ),with the average recovery of 99.8% and RSD of 0.6% .CONCLUSIONS The method was simple,accurate and rapid.The result showed no significant difference in comparison to HPLC.

关 键 词：克林霉素磷酸酯 分光光度法 注射液 高效液相色谱法 

分 类 号：R978.15[医药卫生—药品] R927.2[医药卫生—药学]