更年鼠心肌线粒体ATP酶变化及更年康的作用  

Variation of ATPase in Myocardial Mitochondria of Climacteric Rats and Effect of Geng Nian Kang

作　　者：侯安继[1] 陈友香[1] 鲁遂荣[1] 

机构地区：[1]湖北医科大学附属第二医院中医科,武汉430071

出　　处：《医学新知》1998年第3期23-25,共3页New Medicine

摘　　要：采用大鼠自然更年期模型，观察心肌线粒体Ca2+、Mg2+－ATP酶、Ca2+-ATP酶活性的变化及中药更年康的作用。结果显示模型组大鼠Ca2+、Mg2+-ATP酶、Ca2+-ATP酶活性较青年鼠明显抑制（P＜0．01），而更年康能提高更年鼠心肌线粒体ATP酶活性，提示更年康对于保护心肌线粒体、影响能量代谢、防治更年期心血管疾患具有一定作用。Objective: To observe the variation of Ca2+ 、Mg2+ -ATPase and Ca2+ -AT-Pase in myocardial mitochondria of climacteric rats and the effect of Geng Nian Kang . Methods: A natural animal model of climacteric syndrome was served. 40 SD rats were divided into four groups: model group, Estradiol group. Geng Nian Kang group and normal control. The activity of Ca2+ 、Mg2+ -ATPase and Ca2+ -ATPase were tested.Results: In model group, the results revealed that an inhibition of activity of ca2+ 、Mg2+ -ATPase and Ca2+ -ATPase when it was compared with normal control (P <0. 01). Geng Nian Kang can increase the activity of Ca2+、Mg2+ -ATPase and Ca2+ -ATPase. Conclusion : Geng Nian Kang can protect myocardial mitochondria and has influence on cell energy metabolism , thererore, has some effect on climacteric heart diseases.

关 键 词：线粒体 ATP酶 大鼠 更年期 更年康 心肌能量代谢 

分 类 号：R588[医药卫生—内分泌] R542.2[医药卫生—内科学]