不同方法使用东莨菪碱脱毒效果的比较  

Inhibitory effect of scopolamine on withdrawal syndromes in morphine dependent rats

作　　者：傅强[1] 王新华[1] 石学银[1] 卢洋[2] 汤静兰[1] 

机构地区：[1]第二军医大学长征医院麻醉科,上海200003 [2]科研部国际肿瘤研究所

出　　处：《第二军医大学学报》2001年第4期351-353,共3页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金!资助项目 (39870 75 7)

摘　　要：目的 :观察东莨菪碱 (scopolamine,Spm )和氯丙嗪 (chlopromazine,Clo)对吗啡戒断反应的影响。 方法 :采用吗啡依赖大鼠模型 ,不同剂量单次、多次皮下注射 (sc)东莨菪碱及合并使用氯丙嗪处理动物后 ,腹腔注射 (ip)纳洛酮 5 mg/ kg诱发戒断反应 ,观察戒断症状。 结果 :单次 sc东莨菪碱 1.0 mg/ kg及多次 sc东莨菪碱 0 .5 mg/ kg可明显抑制吗啡依赖大鼠的躯体戒断反应 ,合并注射氯丙嗪 2 0 .0 mg/ kg时的效果更好。结论 :东莨菪碱通过 Ach受体可以抑制吗啡戒断反应 ,氯丙嗪则可能通过作用于蓝斑等中枢部位α2 受体与东莨菪碱起到协同作用。Objective: To observe the inhibitory effect of scopolamine(Spm) and chlopromazine (Clo) on withdrawal syndromes in morphine dependent rats. Methods: The intensity of withdrawal syndromes on the model of morphine dependent rats was recorded after single or muiltiple subcutaneous administration(sc) of Spm and Clo at different doses. Results: Withdrawal syndromes were markedly decreased when single Spm 1 mg/kg and Clo 0.5 mg/kg combined with morphine were injected ( P <0.05). Spm+Clo(sc) had much stronger effects on inhibiting withdrawal syndromes after intraperitoneal (ip) naloxone in morphine dependent rats ( P <0.01). Conclusion: Spm can act on Ach receptor and relieve morphine withdrawal syndromes. Clo may have a synergistic action with Spm via α 2 receptor in the locus coeruleus of the rat brain stem. [

关 键 词：东莨菪碱 氯丙嗪 Ach受体 吗啡戒断症状 大鼠 

分 类 号：R595.5[医药卫生—内科学]