奥美拉唑在慢性乙型肝炎患者中的药动学  

Pharmacokinetics of omeprazole in patients with chronic hepatitis B

作　　者：刘丽萍[1] 孙效东[2] 魏振满[1] 贺承山[1] 刘军[1] 

机构地区：[1]中国人民解放军302医院,北京100039 [2]中国人民解放军总医院,北京100853

出　　处：《中国医院药学杂志》2001年第3期148-150,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：研究慢性乙型肝炎(HBV)患者静脉滴注奥美拉唑(OME)的药动学特性。方法：采用HPLC法测定血浆OME浓度,以3P97程序计算药动学参数。结果：慢性乙型肝炎患者静滴OME的血药浓度曲线符合二室模型,消除半衰期为(3.02±0.24)h,明显长于国内外文献报道的健康人结果,药物清除明显减退,峰浓度明显高于健康人。结论：慢性乙型肝炎患者应用OME时给药剂量可减半或酌情调整。OBJECTIVE：To study the pharmacokinetics of omeprazole (OME) in patients with chronic hepatitis B.METHODS：Plasma concentrations of OME were determined by HPLC,and the pharmacokinetic parameters were computed using 3P97 program.RESULTS：The plasma concentration versus time curve following intravenous 40mg OME in patients with chronic hepatitis B was conicident with two-compartment model,and the elimination half-life was (3.02±0.24)h,which was longer than the value in the healthy volunteers. The peak concentration and CLS in patients with chronic hepatitis B was higher and CLS was lower than the values in the healthy volunteer.CONCLUSIONS：The dosage of OME may be given in the half of a routine dosage or adjusted conditionally for patients with chronic hepatitis B.

关 键 词：奥美拉唑 药动学 慢性乙型肝炎 药物治疗 

分 类 号：R512.62[医药卫生—内科学] R975.2[医药卫生—临床医学]