枸杞子多糖对小鼠白细胞介素-2活性的增强作用(英文)  

Enhancing effect of Lycium barbarum polysaccharides on the interleukin-2 activity in mice

作　　者：耿长山[1] 邢善田[1] 周金黄[1] 储宾孟 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国药理学与毒理学杂志》1989年第3期175-179,共5页Chinese Journal of Pharmacology and Toxicology

摘　　要：本文研究了中药枸杞子的提取物枸杞子多糖（LBP）对成年（2月龄）和老年（16月龄）小鼠脾白细胞介素-2（IL-2）活性的影响，在诱导脾细胞IL-2的培养液（脾细胞5×10^6/ml和ConA4ug/ml）中加入LBP，所制备的含IL-2上清液使成年小鼠胸腺细胞在全外增殖活性（[^3H]TdR参入法）升高，老年小鼠IL-2促进淋巴细胞增殖水平显著低于成年，LBP可使老年小鼠IL-2的这种作用显著提高，达成年水平，这些结果表明，LBP对IL-2的活性有增强作用并使老年小鼠IL-2活性得到恢复。The effect of Lycium barbarum polysaccharidcs(LBP)on the activity of interleukin-2(IL-2)of spleen of adult(2 months old)and aged(16 months old)mice was investigated.When LBP was added to the culture medium to induce production of splenocyte IL-2(splcnocytes 5 ×106/ml and ConA 4μg/ml),the prepared supernatant containing IL-2 increased the proliferation activity of the lymphocytes in vitro of adult mice.The effect of aged mouse IL-2 in promoting the proliferation of lymphocytes was significantly lower than that of the adult animal.LBP could raise this effect of IL-2 of aged mice to the same level as that in adult mice.These results showed that LBP could increase the activity of IL-2 and restore the IL-2 activity of aged mice.

关 键 词：枸杞子多糖 白细胞介素-2 胸腺细胞 淋巴细胞增殖 免疫增强 

分 类 号：R285.5[医药卫生—中药学]