枸橼酸乙胺嗪对狗急性缺氧性肺血管收缩反应的抑制作用  

The inhibitory effects of diethylcarbamazine citrate on hypoxic pulmonary vasoconstriction in dogs

作　　者：李树人[1] 冯长建[1] 陈琪琳 余上斌[1] 胡汉波[1] 王志强[1] 苏运超[1] 王迪浔[1] 

机构地区：[1]同济医科大学病理生理学教研室

出　　处：《中国病理生理杂志》1989年第6期335-338,共4页Chinese Journal of Pathophysiology

摘　　要：本文研究了脂氧酶抑制剂枸橼酸乙胺嗪对狗急性缺氧性肺血管收缩反应的影响。实验结果发现静脉注射枸橼酸乙胺嗪后能明显地抑制血管对缺氧的收缩反应。并且,枸橼酸乙胺嗪对狗缺氧性肺血管收缩反应的抑制作用与其应用后所引起的体动脉压下降和心脏功能受抑制等副作用似无关。从而提示白三烯在狗的缺氧性肺血管收缩反应中可能起介导作用。The effects of diethylcarbamazine citrate (DEC), a lipooxygenase inhibitor, on hypoxic pulmonary vasoconstriction (HPV) in dogs were studied, The results showed that HPV was significantly inhibited after the intravenous administration of DEC, and that the inhibitory effect of DEC on HPV had seemingly no association with the decrease of systemic blood pressure and depression of cardiac function induced by DEC. It is suggested that leukotrienes play a role of mediator in HPV in dogs.

关 键 词：缺氧症 高血压 肺楔压 海群生 慢反应物质A 枸椽酸乙胺嗪 肺血管收缩反应 HPV 

分 类 号：R543.2[医药卫生—心血管疾病] R594.3[医药卫生—内科学]