山莨菪硷及川芎嗪预防大鼠肺水肿的实验研究——肺血管壁通透性变化  

Experimental study of anisodamine and tetramethylpyrarine on prevention of pulmonary edema in rats——Change of pulmonary vascular permeability

作　　者：戴顺龄[1] 薛全福[1] 王树山 李长城[1] 吴云清[1] 贾梅 

机构地区：[1]中国医学科学院基础医学研究所病理生理研究室

出　　处：《中国病理生理杂志》1989年第6期354-357,共4页Chinese Journal of Pathophysiology

摘　　要：山莨菪硷及川芎嗪对大鼠肺水肿有明显的预防作用,在肺水肿发生机理中,肺泡一毛细血管通透性增高是中心环节之一。静脉注射Evans蓝后,先注射肾上腺素造成肺水肿,用山莨菪硷或川芎嗪进行预防,应用本实验方法测定肺脏浸泡液中Evans蓝含量及肺泡支气管洗涤液中Evans蓝含量并算出通透指数。按正常组、肺水肿组、山莨菪硷组、川芎嗪组次序结果为:肺脏浸泡液中Evans蓝含量为6.3±2.6、23.6±7.5、11.3±9.3、15.8±11.0(pg/ml);支气管肺泡洗涤液中Evans蓝通透指数为0.26±0.06、19.1±3.8、1.46±0.56、1.66±1.40,肺水肿组与其他三组均有非常显著性差异,P<0.01。结果说明,肺水肿时肺—毛细血管及肺泡上皮通透性增高,山莨菪硷和川芎嗪能抑制这种增高。In the experiment, we found anisodamine and tetramethylpyrarine show- ed preventive effect On pulmonary edema in rats. Capillary permeability was estimated in this study. The intravenous injection of Evans blue was extracted by formamide from the rat lung by using the improved Keij Udake method, and also gathered from the brocho-alveolar lavage (BAL). It was found that the Evans blue extracted from the pulmonary edema rats lung was 23.6±7.5, which was much higher than that from normal control rats(6.3±2.6) and also much higher than that from anisodamine prevented rats (12.3±9.3) and TMP prevented rats (15.8±11.0). The Evans blue in BAL in pulmonary edema rats was, 19.1±3.8, which was much higher than that from normal control rats (0.26±0.06) and also higher than that from anisodamie prevented rats(0.83±0.37). This result confirmed that anisodamine and TMP could inhibit the increase of pulmonary permeability in rats.

关 键 词：肺血管壁通透性 伊文思蓝 肺水肿 支气管 预防 大鼠 山莨菪硷 川芎嗪 

分 类 号：R541.63[医药卫生—心血管疾病]